articleTop 1% cited

Frequency of single nucleotide polymorphisms in the P-glycoprotein drug transporter MDR1 gene in white subjects

Clinical Pharmacology & Therapeutics · 2001 · Vol. 69(3) · pp. 169–174

Ingolf Cascorbi✉(Humboldt-Universität zu Berlin)

Abstract

This study provides the first analysis of MDR1 variant genotype distribution in a large sample of white subjects. It gives a basis for large-scale clinical investigations on the functional role of MDR1 allelic variants for bioavailability of a substantial number of drugs.

Drug Transport and Resistance Mechanisms Pharmacological Effects and Toxicity Studies Cancer therapeutics and mechanismsGenotypeBiologySingle-nucleotide polymorphismGeneticsAlleleGenotypingExonP-glycoproteinLocus (genetics)Allele frequency

MeSH terms

AdolescentAgedAllelesFemaleGenotypeHumansMaleMiddle AgedPharmacogeneticsPolymorphism, Restriction Fragment LengthPolymerase Chain ReactionGenes, MDRATP Binding Cassette Transporter, Subfamily B, Member 1Polymorphism, Single NucleotideWhite People

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749

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19.75

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100%

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P-glycoprotein: from genomics to mechanism