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AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-Induced Insulin-Resistant Mice

Cell Metabolism · 2011 · Vol. 13(4) · pp. 376–388
Li YuShanqin XuMaria M. MihaylovaBin ZhengXiuyun HouBingbing JiangOgyi ParkZhijun LuoÉtienne LefaiJohn Y.-J. ShyyBin GaoMichel WierzbickiTony J. VerbeurenReuben J. ShawRichard A. CohenMengwei Zang
Metabolism, Diabetes, and CancerDiet, Metabolism, and DiseasePancreatic function and diabetesLipogenesisSterol regulatory element-binding proteinAMPKSteatosisInternal medicinePhosphorylationEndocrinologyInsulin resistanceAMP-activated protein kinaseBiology

MeSH terms

AnimalsBenzopyransDietary FatsDisease Models, AnimalFatty LiverHumansInsulin ResistanceMaleMetforminPhosphorylationReceptors, LDLTranscription, GeneticLipogenesisAtherosclerosisMice
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References
Molecular mediators of hepatic steatosis and liver injury
Journal of Clinical Investigation · 2004 · 1,814 citations
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Journal of Clinical Investigation · 2001 · 5,364 citations
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Journal of Clinical Investigation · 2004 · 1,760 citations
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