article Open AccessTop 1% cited
ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs
Molecular Cell · 2000 · Vol. 6(6) · pp. 1355–1364
Jin Ye(The University of Texas Southwestern Medical Center)Robert B. Rawson(The University of Texas Southwestern Medical Center)Ryutaro Komuro(The University of Texas Southwestern Medical Center)Xi Chen(Columbia University)Utpal P. Davé(The University of Texas Southwestern Medical Center)Ron Prywes(Columbia University)M S Brown✉(The University of Texas Southwestern Medical Center)Joseph L Goldstein✉(The University of Texas Southwestern Medical Center)
Endoplasmic Reticulum Stress and DiseaseRNA regulation and diseaseSignaling Pathways in DiseaseProteasesBiologyCleavage (geology)Cell biologyProcess (computing)Unfolded protein responseProteaseEndoplasmic reticulumBiochemistryEnzyme
MeSH terms
Endoplasmic Reticulum Chaperone BiPAmino Acid SequenceAnimalsCarrier ProteinsCell LineDNA-Binding ProteinsEndoplasmic ReticulumHeat-Shock ProteinsHumansIntracellular MembranesMembrane ProteinsMolecular Sequence DataMutationEndopeptidasesProtein Binding
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References
Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress
Molecular Biology of the Cell · 1999 · 2,020 citations
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