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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
Molecular Cell · 2008 · Vol. 30(2) · pp. 214–226
Dana M. Gwinn(Salk Institute for Biological Studies)David B. Shackelford(Salk Institute for Biological Studies)Daniel F. Egan(Salk Institute for Biological Studies)Maria M. Mihaylova(Salk Institute for Biological Studies)Annabelle Méry(Salk Institute for Biological Studies)Debbie S. Vasquez(Salk Institute for Biological Studies)Benjamin E. Turk(Yale University)Reuben J. Shaw✉(Salk Institute for Biological Studies)
14-3-3 protein interactionsPI3K/AKT/mTOR signaling in cancerMicrotubule and mitosis dynamicsAMPKmTORC1BiologyCell biologyPhosphorylationPI3K/AKT/mTOR pathwayAMP-activated protein kinaseEffectorMechanistic target of rapamycinSerine
MeSH terms
Mechanistic Target of Rapamycin Complex 1Regulatory-Associated Protein of mTORAnimalsCell CycleCell LineHumansMaleMice, Inbred StrainsMultienzyme ComplexesPhosphorylationProteinsSerineSubstrate SpecificityTranscription FactorsApoptosis
Funding
- National Institutes of Health
Citations
3,735
FWCI
64.00
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54
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100%
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References
AMP-Activated Protein Kinase in Metabolic Control and Insulin Signaling
Circulation Research · 2007 · 1,241 citations
Glucose Restriction Extends Caenorhabditis elegans Life Span by Inducing Mitochondrial Respiration and Increasing Oxidative Stress
Cell Metabolism · 2007 · 1,203 citations
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
Nature Cell Biology · 2007 · 1,164 citations
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Nature Reviews Molecular Cell Biology · 2007 · 2,194 citations
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