reviewTop 1% cited

Molecular mechanisms of mTOR-mediated translational control

Nature Reviews Molecular Cell Biology · 2009 · Vol. 10(5) · pp. 307–318

Xiaoju Max✉(Genesys (United States))John Blenis(Harvard University)

PI3K/AKT/mTOR signaling in cancer Polyamine Metabolism and Applications Protein Kinase Regulation and GTPase SignalingPI3K/AKT/mTOR pathwayTranslation (biology)EffectorCell biologySignallingProtein biosynthesisMechanistic target of rapamycinBiologyRPTORComputational biology

MeSH terms

AnimalsGene Expression RegulationHumansProtein KinasesSignal TransductionTOR Serine-Threonine Kinases

Funding

Genentech

Citations

2,525

FWCI

65.21

field-weighted impact

References

126

Percentile

100%

vs. same field & year

Citations per year

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References

The gene encoding the splicing factor SF2/ASF is a proto-oncogene

Nature Structural & Molecular Biology · 2007 · 933 citations

AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism

Cell Metabolism · 2005 · 2,787 citations

Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

Molecular Cell · 2006 · 2,633 citations

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

Oncogene · 2004 · 1,243 citations

Regulation of TORC1 by Rag GTPases in nutrient response

Nature Cell Biology · 2008 · 1,317 citations

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

Nature Cell Biology · 2002 · 3,038 citations

A Rapamycin-Sensitive Pathway Down-Regulates Insulin Signaling via Phosphorylation and Proteasomal Degradation of Insulin Receptor Substrate-1

Molecular Endocrinology · 2000 · 412 citations

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

Current Biology · 2004 · 2,646 citations

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