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The gene encoding the splicing factor SF2/ASF is a proto-oncogene

Nature Structural & Molecular Biology · 2007 · Vol. 14(3) · pp. 185–193

Rotem Karni✉(Cold Spring Harbor Laboratory)Elisa de Stanchina(Cold Spring Harbor Laboratory)Scott W. Lowe(Cold Spring Harbor Laboratory)Rahul Sinha(Cold Spring Harbor Laboratory)David Mu(Cold Spring Harbor Laboratory)Adrian R. Krainer(Cold Spring Harbor Laboratory)

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RNA Research and Splicing RNA and protein synthesis mechanisms RNA modifications and cancerRNA splicingGene isoformAlternative splicingOncogeneGene knockdownCancer researchSplicing factorBiologyKinaseP70-S6 Kinase 1

MeSH terms

Serine-Arginine Splicing FactorsProto-Oncogene MasAnimalsCell Transformation, NeoplasticHeLa CellsHumansMice, NudeNeoplasmsNuclear ProteinsPhosphorylationProto-OncogenesUp-RegulationGene Expression Regulation, NeoplasticRNA-Binding ProteinsApoptosis

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The SR protein family of splicing factors: master regulators of gene expression