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Osamu Takeuchi

Microbial Chemistry Research FoundationORCID https://orcid.org/0000-0002-1260-6232
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Impact (2-yr)
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Top Publications

Pathogen Recognition and Innate Immunity
Cell200611,743 citations
Pattern Recognition Receptors and Inflammation
Cell20108,539 citationsFirst authorCorresponding
Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the <i>Lps</i> Gene Product
The Journal of Immunology19993,357 citations
Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components
Immunity19993,351 citationsFirst author
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Nature Immunology20052,532 citations
Small anti-viral compounds activate immune cells via the TLR7 MyD88–dependent signaling pathway
Nature Immunology20022,484 citations
Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5
The Journal of Experimental Medicine20081,542 citations
Cell Type-Specific Involvement of RIG-I in Antiviral Response
Immunity20051,338 citations
Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins
The Journal of Immunology20021,312 citationsFirst authorCorresponding
Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling
The Journal of Immunology20021,222 citations
Innate immunity to virus infection
Immunological Reviews20081,214 citationsFirst authorCorresponding
Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes
The Journal of Immunology20011,088 citations
Cutting Edge: TLR2-Deficient and MyD88-Deficient Mice Are Highly Susceptible to <i>Staphylococcus aureus</i> Infection
The Journal of Immunology20001,046 citationsFirst authorCorresponding
Osamu Takeuchi · Scinovex