article Open Access
CBP/p300 in cell growth, transformation, and development
Genes & Development · 2000 · Vol. 14(13) · pp. 1553–1577
Richard H. Goodman✉(Vollum Institute)Sarah M. Smolik(Oregon Health & Science University)
Abstract
CREB binding protein (CBP) and p300 were both identified initially in protein interaction assays-the former through its association with the transcription factor CREB The recognition that these two proteins, one involved in transcription and the other in cell transformation, had highly conserved sequences suggested that they had the potential to participate in a variety of cellular functions (Fig. Several excellent reviews
Cancer-related gene regulationUbiquitin and proteasome pathwaysVirus-based gene therapy researchBiologyCREBTranscription factorCoactivatorCREB-binding proteinTransformation (genetics)DNA-binding proteinCell biologyTranscription (linguistics)Genetics
MeSH terms
Amino Acid SequenceAnimalsCell DivisionDNA VirusesEmbryonic and Fetal DevelopmentHumansMolecular Sequence DataNuclear ProteinsOncogenic VirusesPhosphorylationTrans-ActivatorsSequence Homology, Amino Acid
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