review Open AccessTop 1% cited

Mechanisms of Caspase Activation and Inhibition during Apoptosis

Molecular Cell · 2002 · Vol. 9(3) · pp. 459–470

Yigong Shi✉(Princeton University)

Cell death mechanisms and regulation Mitochondrial Function and Pathology PARP inhibition in cancer therapyBiologyCaspaseApoptosomeApoptosisCell biologyIntrinsic apoptosisMechanism (biology)Caspase-9Caspase 2Caspase 3

MeSH terms

AnimalsBinding SitesEnzyme ActivationModels, BiologicalModels, MolecularProtein ConformationProtein PrecursorsProteinsApoptosisProtein Structure, TertiaryInsect ProteinsCaspasesInhibitor of Apoptosis ProteinsCaspase Inhibitors

Citations

1,810

FWCI

46.00

field-weighted impact

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References

An APAF-1·Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

Journal of Biological Chemistry · 1999 · 2,079 citations

Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis

Annual Review of Biochemistry · 1999 · 2,764 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

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Cell · 2000 · 28,385 citations

Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons

Proteins Structure Function and Bioinformatics · 1991 · 5,244 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

Cell · 1997 · 7,227 citations

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

Journal of Biological Chemistry · 1997 · 2,071 citations

Mechanism and role of PDZ domains in signaling complex assembly

Journal of Cell Science · 2001 · 835 citations

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Molecular Cell · 2002 · 1,810 citations

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