review Open AccessTop 1% cited
NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus
Cell Metabolism · 2015 · Vol. 22(1) · pp. 31–53
Carles Cantó✉(Nestlé (Switzerland))Keir J. Menzies(École Polytechnique Fédérale de Lausanne)Johan Auwerx(École Polytechnique Fédérale de Lausanne)
Sirtuins and Resveratrol in MedicineCalcium signaling and nucleotide metabolismPARP inhibition in cancer therapyNAD+ kinaseMitochondrionBiologyCofactorCell biologyMetabolismBiochemistryEnzyme
MeSH terms
AgingAnimalsCell NucleusEnergy MetabolismHomeostasisHumansMetabolic DiseasesMitochondriaNADNeoplasmsPoly(ADP-ribose) PolymerasesNeurodegenerative DiseasesSirtuinsMolecular Targeted Therapy
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References
The Human Sir2 Ortholog, SIRT2, Is an NAD+-Dependent Tubulin Deacetylase
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Cell Metabolism · 2011 · 1,317 citations
Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt
Developmental Cell · 2008 · 802 citations
SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function
Cell Metabolism · 2012 · 1,538 citations
Influence of nicotinic acid on serum cholesterol in man
Archives of Biochemistry and Biophysics · 1955 · 722 citations
The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity
Cell Metabolism · 2012 · 1,217 citations
Evolutionarily Conserved and Nonconserved Cellular Localizations and Functions of Human SIRT Proteins
Molecular Biology of the Cell · 2005 · 1,354 citations
Pre-B-cell colony-enhancing factor, whose expression is up-regulated in activated lymphocytes, is a nicotinamide phosphoribosyltransferase, a cytosolic enzyme involved in NAD biosynthesis
European Journal of Immunology · 2002 · 541 citations
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