article Open AccessTop 1% cited
The Human Sir2 Ortholog, SIRT2, Is an NAD+-Dependent Tubulin Deacetylase
Molecular Cell · 2003 · Vol. 11(2) · pp. 437–444
Brian J. North(University of California, San Francisco)Brett Marshall(University of California, San Francisco)Margie T. Borra(Oregon Health & Science University)John M. Denu(Oregon Health & Science University)Eric Verdin✉(University of California, San Francisco)
Sirtuins and Resveratrol in MedicineAutophagy in Disease and TherapyHistone Deacetylase Inhibitors ResearchBiologySIRT2NAD+ kinaseTubulinSirtuinGeneticsCell biologyCancer researchMicrotubuleBiochemistry
MeSH terms
Histone Deacetylase 6Cell LineHeLa CellsHistone DeacetylasesHumansKineticsMicrotubulesNADRecombinant ProteinsSubstrate SpecificityTubulinSirtuinsSilent Information Regulator Proteins, Saccharomyces cerevisiaeSirtuin 2In Vitro Techniques
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References
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
Nucleic Acids Research · 1983 · 11,601 citations
Phylogenetic Classification of Prokaryotic and Eukaryotic Sir2-like Proteins
Biochemical and Biophysical Research Communications · 2000 · 1,387 citations
Characterization of Five Human cDNAs with Homology to the Yeast SIR2 Gene: Sir2-like Proteins (Sirtuins) Metabolize NAD and May Have Protein ADP-Ribosyltransferase Activity
Biochemical and Biophysical Research Communications · 1999 · 805 citations
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