article Open AccessTop 1% cited
SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function
Cell Metabolism · 2012 · Vol. 15(5) · pp. 675–690
Nathan L. Price(Harvard University)Ana P. Gomes(Harvard University)Alvin J. Y. Ling(Harvard University)Filipe V. DuarteAlejandro Martín‐Montalvo(National Institutes of Health)Brian J. North(Harvard University)Beamon Agarwal(University of Pennsylvania)Lan Ye(University of Pennsylvania)Giorgio Ramadori(The University of Texas Southwestern Medical Center)João S. TeodoroBasil P. Hubbard(Harvard University)Ana VarelaJames G. Davis(University of Pennsylvania)Behzad Varamini(University of Pennsylvania)Angela Hafner(Harvard University)Ruin Moaddel(National Institute on Aging)Anabela P. Rolo(University of Aveiro)Roberto Coppari(Marche Polytechnic University)Carlos M. Palmeira(University of Coimbra)Rafael de Cabo(National Institutes of Health)Joseph A. Baur(University of Pennsylvania)David Sinclair✉(Harvard University)
Sirtuins and Resveratrol in MedicineAutophagy in Disease and TherapyAdipose Tissue and MetabolismResveratrolAMPKFunction (biology)Sirtuin 1AMP-activated protein kinaseMitochondrionChemistryCell biologyPharmacologyBiochemistry
MeSH terms
ResveratrolAMP-Activated Protein Kinase KinasesAnimalsCells, CulturedEnzyme ActivationMice, Inbred C57BLMitochondriaNADProtein KinasesStilbenesSignal TransductionMice, KnockoutMuscle, SkeletalHepatocytesMice
Funding
- National Institutes of Health
- National Center for Research Resources
Citations
1,538
FWCI
59.47
field-weighted impact
References
104
Percentile
100%
vs. same field & year
Citations per year
Cited by
Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives
Cells · 2020 · 1,137 citations
NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus
Cell Metabolism · 2015 · 1,554 citations
Resveratrol (RV): A pharmacological review and call for further research
Biomedicine & Pharmacotherapy · 2021 · 484 citations
Mitochondrial Dysfunction in Neurodegenerative Diseases
Journal of Pharmacology and Experimental Therapeutics · 2012 · 802 citations
Small molecule SIRT1 activators for the treatment of aging and age-related diseases
Trends in Pharmacological Sciences · 2014 · 561 citations
The Hallmarks of Aging
Cell · 2013 · 14,515 citations
References
Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt
Developmental Cell · 2008 · 802 citations
Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss
Cell stem cell · 2007 · 800 citations
Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients
British Journal Of Nutrition · 2011 · 655 citations
Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span
Cell Metabolism · 2008 · 1,147 citations
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α
The EMBO Journal · 2007 · 1,271 citations
Resveratrol induces mitochondrial biogenesis in endothelial cells
American Journal of Physiology-Heart and Circulatory Physiology · 2009 · 442 citations
Therapeutic potential of resveratrol: the in vivo evidence
Nature Reviews Drug Discovery · 2006 · 3,859 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.