reviewTop 10% cited
Stability of Protein Pharmaceuticals
Pharmaceutical Research · 1989 · Vol. 6(11) · pp. 903–918
Mark C. Manning✉(University of Kansas)Kamlesh C. Patel(University of Kansas)Ronald T. Borchardt(University of Kansas)
Protein purification and stabilityProtein Structure and DynamicsEnzyme Structure and FunctionDeamidationDenaturation (fissile materials)ChemistryProteolysisRacemizationProtein engineeringMutagenesisProtein aggregationBiopharmaceuticalProtein stability
MeSH terms
Chemistry, PharmaceuticalDrug StabilityProteins
Citations
1,072
FWCI
5.18
field-weighted impact
References
339
Percentile
97%
vs. same field & year
Citations per year
Cited by
Crystallization processes in pharmaceutical technology and drug delivery design
Journal of Crystal Growth · 2000 · 414 citations
Biodegradable microspheres for protein delivery
Journal of Controlled Release · 2003 · 800 citations
Instability, stabilization, and formulation of liquid protein pharmaceuticals
International Journal of Pharmaceutics · 1999 · 1,052 citations
Rational Design of Stable Lyophilized Protein Formulations: Some Practical Advice
Pharmaceutical Research · 1997 · 671 citations
Challenges in the development of high protein concentration formulations
Journal of Pharmaceutical Sciences · 2004 · 861 citations
Effects of glycosylation on the stability of protein pharmaceuticals
Journal of Pharmaceutical Sciences · 2008 · 636 citations
Physical Stability of Proteins in Aqueous Solution: Mechanism and Driving Forces in Nonnative Protein Aggregation
Pharmaceutical Research · 2003 · 1,362 citations
Lyophilization and development of solid protein pharmaceuticals
International Journal of Pharmaceutics · 2000 · 1,143 citations
References
Mechanism of protein stabilization by glycerol: preferential hydration in glycerol-water mixtures
Biochemistry · 1981 · 1,178 citations
Theory for the folding and stability of globular proteins
Biochemistry · 1985 · 1,255 citations
A Protein Sequenator
European Journal of Biochemistry · 1967 · 2,841 citations
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
Nature · 1970 · 251,243 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.