reviewTop 10% cited

Effects of glycosylation on the stability of protein pharmaceuticals

Journal of Pharmaceutical Sciences · 2008 · Vol. 98(4) · pp. 1223–1245

Ricardo J. Solá✉(University of Puerto Rico at Río Piedras)Kai Griebenow✉(University of Puerto Rico at Río Piedras)

Protein purification and stability Glycosylation and Glycoproteins Research Monoclonal and Polyclonal Antibodies ResearchGlycosylationGlycanGlycoproteinProtein stabilityChemistryRational designIn vivoComputational biologyBiochemical engineeringBiochemistry

MeSH terms

Drug StabilityPharmaceutical PreparationsGlycosylationModels, ChemicalPolymersPolysaccharidesProtein DenaturationProteinsProtein EngineeringProtein Stability

Funding

Amgen
Biogen

Citations

636

FWCI

7.17

field-weighted impact

References

238

Percentile

98%

vs. same field & year

Citations per year

Cited by

Stability of Protein Pharmaceuticals: An Update

Pharmaceutical Research · 2010 · 1,076 citations

References

Stability of Protein Pharmaceuticals

Pharmaceutical Research · 1989 · 1,072 citations

Protein Instability in Poly(Lactic-co-Glycolic Acid) Microparticles

Pharmaceutical Research · 2000 · 696 citations

Physical Stability of Proteins in Aqueous Solution: Mechanism and Driving Forces in Nonnative Protein Aggregation

Pharmaceutical Research · 2003 · 1,362 citations

Protein glycosylation

European Journal of Biochemistry · 1993 · 829 citations

Infrared Spectroscopic Studies of Lyophilization‐ and Temperature‐Induced Protein Aggregation

Journal of Pharmaceutical Sciences · 1995 · 457 citations

On the frequency of protein glycosylation, as deduced from analysis of the SWISS-PROT database

Biochimica et Biophysica Acta (BBA) - General Subjects · 1999 · 1,854 citations

Structure-Immunogenicity Relationships of Therapeutic Proteins

Pharmaceutical Research · 2004 · 617 citations

Lyophilization and development of solid protein pharmaceuticals

International Journal of Pharmaceutics · 2000 · 1,143 citations

Citation Network

How this paper connects to the literature. Drag to explore, click any node to open that paper.