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Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction

Nature Methods · 2020 · Vol. 17(12) · pp. 1214–1221
Ali PunjaniHaowei ZhangDavid J. Fleet
Advanced Electron Microscopy Techniques and ApplicationsElectron and X-Ray Spectroscopy TechniquesAdvanced X-ray Imaging TechniquesRegularization (linguistics)AlgorithmComputer scienceParticle (ecology)Computational biologyBiological systemPhysicsArtificial intelligenceBiology

MeSH terms

AlgorithmsMembrane ProteinsSoftwareCryoelectron MicroscopyImaging, Three-DimensionalIntrinsically Disordered Proteins

Funding

  • Canadian Institute for Advanced Research
  • Government of Canada
  • Vector Institute
  • Natural Sciences and Engineering Research Council of Canada
Citations
1,782
FWCI
113.52
field-weighted impact
References
48
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100%
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Citations per year
References
How many drug targets are there?
Nature Reviews Drug Discovery · 2006 · 3,473 citations
Maximum Likelihood from Incomplete Data Via the <i>EM</i> Algorithm
Journal of the Royal Statistical Society Series B (Statistical Methodology) · 1977 · 49,286 citations
Quantifying the local resolution of cryo-EM density maps
Nature Methods · 2013 · 1,970 citations
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Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction · Scinovex