reviewTop 1% cited
How many drug targets are there?
Nature Reviews Drug Discovery · 2006 · Vol. 5(12) · pp. 993–996
John P. Overington✉(Mundipharma (United Kingdom))Bissan Al‐Lazikani(Mundipharma (United Kingdom))Andrew L. Hopkins(Pfizer (United Kingdom))
Computational Drug Discovery MethodsClick Chemistry and ApplicationsMonoclonal and Polyclonal Antibodies ResearchDrug discoveryDrugApproved drugDrug repositioningMedicineDrug approvalDrug developmentPharmacologyBioinformaticsBiology
MeSH terms
HumansTechnology, PharmaceuticalDrug DesignDrugs, InvestigationalGenome, HumanDrug Delivery SystemsDrug Approval
Citations
3,473
FWCI
85.99
field-weighted impact
References
29
Percentile
100%
vs. same field & year
Citations per year
Cited by
Biased agonism: An emerging paradigm in GPCR drug discovery
Bioorganic & Medicinal Chemistry Letters · 2015 · 269 citations
Regulation of autophagy by mTOR-dependent and mTOR-independent pathways: autophagy dysfunction in neurodegenerative diseases and therapeutic application of autophagy enhancers
Biochemical Society Transactions · 2013 · 363 citations
Diversity-oriented synthesis; a spectrum of approaches and results
Organic & Biomolecular Chemistry · 2008 · 280 citations
A comprehensive map of molecular drug targets
Nature Reviews Drug Discovery · 2016 · 2,383 citations
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
Oncogene · 2007 · 2,782 citations
Diagnosing the decline in pharmaceutical R&D efficiency
Nature Reviews Drug Discovery · 2012 · 1,911 citations
Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction
Nature Methods · 2020 · 1,782 citations
Designing antimicrobial peptides: form follows function
Nature Reviews Drug Discovery · 2011 · 1,976 citations
References
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells
Nature Medicine · 1996 · 3,643 citations
The druggable genome
Nature Reviews Drug Discovery · 2002 · 3,271 citations
SCOP: A structural classification of proteins database for the investigation of sequences and structures
Journal of Molecular Biology · 1995 · 6,318 citations
The Protein Data Bank
Nucleic Acids Research · 2000 · 39,191 citations
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
Advanced Drug Delivery Reviews · 2001 · 17,620 citations
The Pfam Protein Families Database
Nucleic Acids Research · 2002 · 14,220 citations
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
Advanced Drug Delivery Reviews · 1997 · 11,043 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.
