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Distribution of ACE2, CD147, CD26, and other SARS‐CoV‐2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID‐19 risk factors

Allergy · 2020 · Vol. 75(11) · pp. 2829–2845

Urszula Radzikowska(Medical University of Białystok)Mei Ding(University of Zurich)Ge Tan(University of Zurich)Damir Zhakparov(University of Zurich)Yaqi Peng(Sun Yat-sen University)Paulina Wawrzyniak(University of Zurich)Ming Wang(Beijing Tongren Hospital)Shuo Li(Oslo University Hospital)Hideaki Morita(University of Zurich)Can Altunbulakli(University of Zurich)Matthias Reiger(Helmholtz Zentrum München)Avidan U. Neumann(Helmholtz Zentrum München)Nonhlanhla Lunjani(University of Zurich)Claudia Traidl‐Hoffmann(Helmholtz Zentrum München)Kari C. Nadeau(Stanford University)Liam O’Mahony(National University of Ireland)Cezmi A. Akdiş(University of Zurich)Milena Sokołowska✉(University of Zurich)

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Abstract

Our data suggest different receptor repertoire potentially involved in the SARS-CoV-2 infection at the epithelial barriers and in the immune cells. Altered expression of these receptors related to age, gender, obesity and smoking, as well as with the disease status, might contribute to COVID-19 morbidity and severity patterns.

Signaling Pathways in Disease COVID-19 Clinical Research Studies Adipokines, Inflammation, and Metabolic DiseasesImmunologyImmune systemMedicinePeripheral blood mononuclear cellAsthmaCOPDBronchoalveolar lavageCD8LungBiology

MeSH terms

Angiotensin-Converting Enzyme 2COVID-19SARS-CoV-2AdolescentAdultAge FactorsAgedAsthmaChildChild, PreschoolChronic DiseaseFemaleHumansHypertensionImmunity, Innate