article Open AccessTop 1% cited
SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Cell · 2020 · Vol. 181(2) · pp. 271–280.e8
Markus Hoffmann✉(German Primate Center)Hannah Kleine‐Weber(German Primate Center)Simon Schroeder(Charité - Universitätsmedizin Berlin)Nadine Krüger(University of Veterinary Medicine Hannover, Foundation)Tanja Herrler(Berufsgenossenschaftliche Unfallklinik Murnau)Sandra Erichsen(Berufsgenossenschaftliche Unfallklinik Murnau)Tobias S. Schiergens(Ludwig-Maximilians-Universität München)Georg Herrler(University of Veterinary Medicine Hannover, Foundation)Nai-Huei Wu(University of Veterinary Medicine Hannover, Foundation)Andreas Nitsche(Robert Koch Institute)Marcel A. Müller(Sechenov University)Christian Drosten(Charité - Universitätsmedizin Berlin)Stefan Pöhlmann(University of Göttingen)
SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesViral Infections and Outbreaks ResearchTMPRSS2ProteasesBiologyViral entryVirologyCoronavirusProteaseReceptorSerine proteaseSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
MeSH terms
BetacoronavirusDrug DevelopmentAngiotensin-Converting Enzyme 2COVID-19SARS-CoV-2COVID-19 SerotherapyAmmonium ChlorideAnimalsAntibodies, ViralCell LineEstersGuanidinesHumansImmunization, PassivePeptidyl-Dipeptidase A
Funding
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung und Forschung
Citations
21,183
FWCI
472.54
field-weighted impact
References
67
Percentile
100%
vs. same field & year
Citations per year
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Nature Medicine · 2005 · 3,627 citations
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A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry
Journal of Virology · 2010 · 757 citations
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The Journal of Pathology · 2004 · 5,896 citations
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Nature Reviews Microbiology · 2016 · 3,707 citations
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