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ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19
European Respiratory Journal · 2020 · Vol. 55(5) · pp. 2000688–2000688
Janice M. Leung✉(St. Paul's Hospital)Chen Xi Yang(St. Paul's Hospital)Anthony Raymond Tam(University of British Columbia)Tawimas Shaipanich(University of British Columbia)Tillie‐Louise Hackett(University of British Columbia)Gurpreet K. Singhera(St. Paul's Hospital)Delbert R. Dorscheid(St. Paul's Hospital)Don D. Sin(University of British Columbia)
Abstract
<b>Smokers and those with COPD have increased airway expression of ACE-2, which is the entry receptor for the COVID-19 virus. This may explain the increased risk of severe COVID-19 in these subpopulations and highlight the importance of smoking cessation.</b>https://bit.ly/3bC29es
Asthma and respiratory diseasesChronic Obstructive Pulmonary Disease (COPD) ResearchCancer, Stress, Anesthesia, and Immune ResponseMedicineCOPDCoronavirus disease 2019 (COVID-19)AirwaySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakReceptorSmoking cessationVirusInternal medicine
MeSH terms
SmokersRNA-SeqAngiotensin-Converting Enzyme 2COVID-19AdultEpitheliumFemaleHumansPeptidyl-Dipeptidase ALungMaleMiddle AgedPneumonia, ViralRespiratory SystemSmoking
Funding
- Canadian Institutes of Health Research
Citations
852
FWCI
93.44
field-weighted impact
References
20
Percentile
100%
vs. same field & year
Citations per year
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Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China
JAMA · 2020 · 17,926 citations
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