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Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

Nature Immunology · 2019 · Vol. 20(3) · pp. 326–336

Brian C. Miller✉(Broad Institute)Debattama R. Sen(Broad Institute)Rose Al Abosy(Broad Institute)Kevin Bi(Broad Institute)Yamini V. Virkud(Massachusetts General Hospital)Martin W. LaFleur(Broad Institute)Kathleen B. Yates(Broad Institute)Ana Lako(Dana-Farber Cancer Institute)Kristen D. Felt(Dana-Farber Cancer Institute)Girish S. Naik(Dana-Farber Cancer Institute)Michael P. Manos(Dana-Farber Cancer Institute)Evisa Gjini(Dana-Farber Cancer Institute)Juhi R. Kuchroo(Brigham and Women's Hospital)Jeffrey J. Ishizuka(Broad Institute)Jenna L. Collier(Broad Institute)Gabriel K. Griffin(Broad Institute)Seth Maleri(Brigham and Women's Hospital)Dawn E. Comstock(Broad Institute)Sarah A. Weiss(Broad Institute)Flavian D. Brown(Broad Institute)Arpit Panda(Broad Institute)Margaret D. Zimmer(Broad Institute)Robert T. Manguso(Broad Institute)F. Stephen Hodi(Dana-Farber Cancer Institute)Scott J. Rodig(Brigham and Women's Hospital)Arlene H. Sharpe(Broad Institute)W. Nicholas Haining(Broad Institute)

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Cancer Immunotherapy and Biomarkers CAR-T cell therapy research Immune Cell Function and InteractionBlockadeProgenitor cellCD8ProgenitorImmunologyCytotoxic T cellCancer researchImmune checkpointMedicineBiology

MeSH terms

AnimalsFemaleHumansLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMelanoma, ExperimentalMice, Inbred C57BLLymphocyte SubsetsLymphocytes, Tumor-InfiltratingCD8-Positive T-LymphocytesAntibodies, BlockingMice, CongenicCell Line, TumorProgrammed Cell Death 1 Receptor

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Tumor antigen–specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired