review Open AccessTop 1% cited

Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease

Journal of Hepatology · 2018 · Vol. 69(4) · pp. 927–947

Cynthia Lebeaupin✉(Université Côte d'Azur)Déborah Vallée(Inserm)Younis Hazari(Instituto de Neurociencia Biomédica)Claudio Hetz(Harvard University)Éric Chevet(Centre Eugène Marquis)Béatrice Bailly‐Maitre(Inserm)

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Endoplasmic Reticulum Stress and Disease Liver Disease Diagnosis and Treatment Pancreatic function and diabetesEndoplasmic reticulumFatty liverPathogenesisAlcoholic liver diseaseSignallingDiseaseUnfolded protein responseCell biologyMedicineInternal medicine

MeSH terms

AnimalsAutophagyCalciumHumansInsulin ResistanceSulfonamidesThiophenesGenetic TherapySignal TransductionLipid MetabolismActivating Transcription Factor 6Unfolded Protein ResponseEndoplasmic Reticulum StressNon-alcoholic Fatty Liver Disease

Funding

Association pour la Recherche sur le Cancer
Société Française de Dermatologie et de Pathologie Sexuellement Transmissible
Institut National Du Cancer
Association Française pour l'Etude du Foie

Citations

924

FWCI

31.87

field-weighted impact

References

220

Percentile

100%

vs. same field & year

Citations per year

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References

ER stress induces NLRP3 inflammasome activation and hepatocyte death

Cell Death and Disease · 2015 · 393 citations

Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

Journal of Clinical Investigation · 2005 · 3,421 citations

ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization Signals

Developmental Cell · 2002 · 1,429 citations

Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

Cell Death and Disease · 2014 · 619 citations

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

Cell Metabolism · 2010 · 1,246 citations

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

Nature Immunology · 2009 · 2,599 citations

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

eLife · 2015 · 646 citations

The eIF2α kinases: their structures and functions

Cellular and Molecular Life Sciences · 2013 · 831 citations

Signal integration in the endoplasmic reticulum unfolded protein response

Nature Reviews Molecular Cell Biology · 2007 · 6,243 citations

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