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Comparative genome and phenotypic analysis of three Clostridioides difficile strains isolated from a single patient provide insight into multiple infection of C. difficile

BMC Genomics · 2018 · Vol. 19(1) · pp. 1–1

Uwe Groß✉(Universitätsmedizin Göttingen)Elżbieta Brzuszkiewicz(University of Göttingen)Katrin Gunka(Universitätsmedizin Göttingen)Jessica Starke(University of Göttingen)Thomas Riedel(German Center for Infection Research)Boyke Bunk(Leibniz Institute DSMZ – German Collection of Microorganisms and Cell Cultures)Cathrin Spröer(Leibniz Institute DSMZ – German Collection of Microorganisms and Cell Cultures)Daniela Wetzel(Universitätsmedizin Göttingen)Anja Poehlein(University of Göttingen)Cynthia Maria Chibani(University of Göttingen)Wolfgang Bohne(Universitätsmedizin Göttingen)Jörg Overmann(German Center for Infection Research)Ortrud Zimmermann(Universitätsmedizin Göttingen)Rolf Daniel(University of Göttingen)Heiko Liesegang(University of Göttingen)

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Abstract

Our findings show that (i) evolutionary events based on horizontal gene transfer occur within an ongoing CDI and contribute to the adaptation of the species by the introduction of new genes into the genomes, (ii) within a multiple infection of a single patient the exchange of genetic material was responsible for a much higher genome variation than the observed SNPs.

Clostridium difficile and Clostridium perfringens research Helicobacter pylori-related gastroenterology studies Gut microbiota and healthClostridioidesBiologyPhenotypeGenomeC difficileClostridium difficileComputational biologyGeneticsDNA microarrayMicrobiology