article Open AccessTop 1% cited
ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase
Nature Cell Biology · 2013 · Vol. 15(7) · pp. 741–750
Ryan C. Russell✉(University of California, San Diego)Ye Tian(University of California, Berkeley)Hai‐Xin Yuan(University of California, San Diego)Hyun Woo Park(University of California, San Diego)Yu-Yun Chang(University of Minnesota)Joungmok Kim(University of California, San Diego)Haerin Kim(University of California, San Diego)Thomas P. Neufeld(University of Minnesota)Andrew Dillin(University of California, Berkeley)Kun‐Liang Guan(University of California, San Diego)
Autophagy in Disease and TherapyEndoplasmic Reticulum Stress and DiseaseAutophagyULK1Cell biologyAutophagy-related protein 13KinasePhosphorylationPI3K/AKT/mTOR pathwayProtein kinase ABiologyBiochemistry
MeSH terms
Autophagy-Related ProteinsBeclin-1Autophagy-Related Protein-1 HomologAmino AcidsAnimalsAutophagyCells, CulturedEmbryo, MammalianEnzyme ActivationFibroblastsHumansKidneyPhosphorylationSerineStarvation
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References
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Nature Cell Biology · 2011 · 6,906 citations
Autophagy: Renovation of Cells and Tissues
Cell · 2011 · 6,245 citations
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
Nature Cell Biology · 2009 · 1,189 citations
Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells
The EMBO Journal · 2000 · 1,117 citations
Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes
Journal of Cell Science · 2006 · 799 citations
ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
Molecular Biology of the Cell · 2009 · 1,973 citations
JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy
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Molecular Biology of the Cell · 2008 · 1,140 citations
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