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Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel

European Heart Journal · 2017 · Vol. 38(32) · pp. 2459–2472
Brian A. FerenceHenry N. GinsbergIan GrahamKausik K. RayChris J. PackardÉric BruckertRobert A. HegeleRonald M. KraussFrederick J. RaalHeribert SchunkertGerald F. WattsJan BorénSergio FazioJay D. HortonL. MasanaStephen J. NichollsBørge G. NordestgaardBart van de SluisMarja‐Riitta TaskinenLâle TokgözoğluUlf LandmesserUlrich LaufsOlov WiklundJane K. StockM. John ChapmanAlberico L. Catapano

Abstract

Consistent evidence from numerous and multiple different types of clinical and genetic studies unequivocally establishes that LDL causes ASCVD.

Lipoproteins and Cardiovascular HealthCancer, Lipids, and MetabolismDiabetes, Cardiovascular Risks, and LipoproteinsMedicineConsensus conferenceAtherosclerotic cardiovascular diseaseStatement (logic)DiseaseInternal medicineCardiologyLaw

MeSH terms

EzetimibeProprotein Convertase 9PCSK9 InhibitorsAnticholesteremic AgentsEpidemiologic MethodsHyperlipidemiasCholesterol, HDLLipoproteins, LDLCholesterol, LDLHydroxymethylglutaryl-CoA Reductase InhibitorsGenetic Predisposition to DiseaseConsensusAtherosclerosis

Funding

  • Amgen
  • Eli Lilly and Company
  • Pfizer
  • AstraZeneca
  • GlaxoSmithKline
  • Sanofi
  • Alnylam Pharmaceuticals
  • Danone
  • CSL Behring
  • Regeneron Pharmaceuticals
  • Amarin Corporation
  • Anthera
  • Medicines Company
  • Kowa Company
  • Mylan
  • InfraRedx
  • Daiichi-Sankyo
  • Novo Nordisk
  • Servier
  • Esperion Therapeutics
  • Bayer Vital
Citations
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