review Open AccessTop 1% cited
mTOR Signaling in Growth, Metabolism, and Disease
Cell · 2017 · Vol. 168(6) · pp. 960–976
Robert A. Saxton✉(Whitehead Institute for Biomedical Research)David M. Sabatini(Allen Institute)
PI3K/AKT/mTOR signaling in cancerPolyamine Metabolism and ApplicationsMetabolism, Diabetes, and CancerPI3K/AKT/mTOR pathwayAutophagyBiologymTORC2Mechanistic target of rapamycinRPTORSignal transductionCell biologyTOR signalingFunction (biology)
MeSH terms
AgingAnimalsDiabetes MellitusGlucoseHumansMusclesNeoplasmsSignal TransductionTOR Serine-Threonine Kinases
Funding
- U.S. Department of Defense
- Howard Hughes Medical Institute
- National Institutes of Health
Citations
7,263
FWCI
285.22
field-weighted impact
References
189
Percentile
100%
vs. same field & year
Citations per year
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References
Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways
Nature Cell Biology · 2001 · 1,559 citations
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
Nature Cell Biology · 2001 · 2,692 citations
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
Nature Cell Biology · 2011 · 6,906 citations
Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
Molecular Cell · 2010 · 1,954 citations
Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB
Molecular Cell · 2006 · 2,633 citations
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
Biochemical Journal · 2008 · 884 citations
The TSC1–TSC2 complex: a molecular switchboard controlling cell growth
Biochemical Journal · 2008 · 1,234 citations
Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1
Developmental Cell · 2006 · 1,398 citations
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