review Open AccessTop 1% cited

A guide to immunometabolism for immunologists

Nature reviews. Immunology · 2016 · Vol. 16(9) · pp. 553–565

Luke O'neill✉(Trinity College Dublin)Rigel J. Kishton(Vanderbilt University Medical Center)Jeff Rathmell(Vanderbilt University Medical Center)

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Immune Cell Function and Interaction Immune cells in cancer Immune Response and InflammationPentose phosphate pathwayMetabolic pathwayGlycolysisCitric acid cycleImmune systemBiologyMetabolismFatty acid metabolismBeta oxidationBiochemistry

MeSH terms

AnimalsHumansImmune System

Citations

2,917

FWCI

89.23

field-weighted impact

References

102

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100%

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Citations per year

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References

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Nature Medicine · 2003 · 2,279 citations

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

Immunity · 2011 · 1,474 citations

Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation

Cell Metabolism · 2006 · 1,309 citations

Arginase-1–Expressing Macrophages Suppress Th2 Cytokine–Driven Inflammation and Fibrosis

PLoS Pathogens · 2009 · 796 citations

Inhibition of T Cell Proliferation by Macrophage Tryptophan Catabolism

The Journal of Experimental Medicine · 1999 · 1,603 citations

Glucose-Independent Glutamine Metabolism via TCA Cycling for Proliferation and Survival in B Cells

Cell Metabolism · 2012 · 1,086 citations

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

Immunity · 2015 · 1,928 citations

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

Immunity · 2011 · 2,061 citations

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