articleTop 1% cited
Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
Nature Medicine · 2003 · Vol. 9(10) · pp. 1269–1274
Catherine Uyttenhove✉(Ludwig Cancer Research)Luc Pilotte(Ludwig Cancer Research)Ivan Théate(UCLouvain)Vincent Stroobant(Ludwig Cancer Research)Didier Colau(Ludwig Cancer Research)Nicolas Parmentier(Ludwig Cancer Research)Thierry Boon(Ludwig Cancer Research)Benoı̂t J. Van den Eynde(Ludwig Cancer Research)
Tryptophan and brain disordersCancer, Stress, Anesthesia, and Immune ResponseImmune cells in cancerIndoleamine 2,3-dioxygenaseImmune systemTryptophanCancer researchEconomic shortageImmune toleranceImmunologyTryptophan MetabolismBiologyChemistry
MeSH terms
AnimalsFemaleHumansNeoplasm TransplantationNeoplasmsPlacentaPregnancyRNA, MessengerTryptophanTryptophan OxygenaseCD8-Positive T-LymphocytesTumor EscapeCell Line, TumorIndoleamine-Pyrrole 2,3,-DioxygenaseMice
Citations
2,279
FWCI
26.73
field-weighted impact
References
40
Percentile
100%
vs. same field & year
Citations per year
Cited by
Immunosuppressive Strategies that are Mediated by Tumor Cells
Annual Review of Immunology · 2006 · 1,705 citations
Species Variation in the Mechanisms of Mesenchymal Stem Cell-Mediated Immunosuppression
Stem Cells · 2009 · 586 citations
Natural Innate and Adaptive Immunity to Cancer
Annual Review of Immunology · 2011 · 2,024 citations
Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase–mediated tryptophan degradation
Blood · 2004 · 1,627 citations
Classification of current anticancer immunotherapies
Oncotarget · 2014 · 467 citations
Up-Regulation of PD-L1, IDO, and T <sub>regs</sub> in the Melanoma Tumor Microenvironment Is Driven by CD8 <sup>+</sup> T Cells
Science Translational Medicine · 2013 · 1,662 citations
The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor ζ-Chain and Induce a Regulatory Phenotype in Naive T Cells
The Journal of Immunology · 2006 · 1,030 citations
References
Inhibition of T Cell Proliferation by Macrophage Tryptophan Catabolism
The Journal of Experimental Medicine · 1999 · 1,603 citations
Tumor regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by geneMAGE-3 and presented by HLA-A1
International Journal of Cancer · 1999 · 786 citations
Vaccination of melanoma patients with peptide- or tumorlysate-pulsed dendritic cells
Nature Medicine · 1998 · 2,862 citations
T cell apoptosis by tryptophan catabolism
Cell Death and Differentiation · 2002 · 1,005 citations
Citation Network
How this paper connects to the literature. Drag to explore, click any node to open that paper.
