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Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

Immunity · 2015 · Vol. 42(3) · pp. 419–430

Abhishek Jha(Agios Pharmaceuticals (United States))Stanley Ching‐Cheng Huang(Washington University in St. Louis)Alexey Sergushichev(ITMO University)Vicky Lampropoulou(Washington University in St. Louis)Yulia Ivanova(Washington University in St. Louis)Ekaterina Loginicheva(Washington University in St. Louis)Karina Chmielewski(Agios Pharmaceuticals (United States))Kelly M. Stewart(Agios Pharmaceuticals (United States))Juliet Ashall(Washington University in St. Louis)Bart Everts(Washington University in St. Louis)Edward J. Pearce(Washington University in St. Louis)Edward M. Driggers✉(Agios Pharmaceuticals (United States))Maxim N. Artyomov✉(Washington University in St. Louis)

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Immune cells in cancer Epigenetics and DNA Methylation Single-cell and spatial transcriptomicsMacrophage polarizationBiologyMetabolic pathwayCatabolismGlutamineMetabolic networkCell biologyNitric oxideCrosstalkEnzyme

MeSH terms

AnimalsArgininosuccinic AcidAspartic AcidCitric Acid CycleGene Expression RegulationGlutamineGlycosylationImmunity, InnateIsocitrate DehydrogenaseMacrophagesMitochondriaNitric OxideTranscription, GeneticUridine Diphosphate N-AcetylglucosamineSignal Transduction

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