reviewTop 1% cited
The phosphatidylinositol 3-Kinase–AKT pathway in human cancer
Nature reviews. Cancer · 2002 · Vol. 2(7) · pp. 489–501
Igor Vivanco✉(University of California, Los Angeles)Charles L. Sawyers
PI3K/AKT/mTOR signaling in cancerProtein Kinase Regulation and GTPase SignalingCell death mechanisms and regulationPhosphatidylinositolPI3K/AKT/mTOR pathwayKinaseProtein kinase BCell biologyMotilityBiologyCancerChemistryCancer research
MeSH terms
AnimalsCell DivisionDisease Models, AnimalHumansLipidsModels, BiologicalNeoplasmsPhenotypeProto-Oncogene ProteinsProtein BiosynthesisSignal TransductionProtein Serine-Threonine KinasesGene DeletionPhosphatidylinositol PhosphatesPhosphatidylinositol 3-Kinases
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References
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Nature Cell Biology · 2001 · 2,692 citations
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Biochemical Journal · 2000 · 1,590 citations
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Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
Biochemical Journal · 1999 · 918 citations
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