Resolvins: The resolving mediators divulged

Abstract

Resolution pharmacology has gained paramount importance in the field of medicine. Resolvins are specialized pro-resolving lipid mediators (SPMs). They are natural bioactive agents involved in the resolution of inflammation. They function when uncontrolled inflammatory processes are developed. Lipoxins, resolvins, protectins, and maresins are families of mediators that are under SPM. In recent years it has become evident that periodontitis is a multifactorial inflammatory disease initiated by oral microbial biofilm. This review focuses on understanding the role of resolvins, endogenous lipid mediators in overall oral health, and periodontal inflammation that modulate cellular fate and resolution.