review Open AccessTop 1% cited
An updated evolutionary classification of CRISPR–Cas systems
Nature Reviews Microbiology · 2015 · Vol. 13(11) · pp. 722–736
Kira S. Makarova✉(National Institutes of Health)Yuri I. Wolf(National Institutes of Health)Omer S. Alkhnbashi(TU Bergakademie Freiberg)Fabrizio Costa(TU Bergakademie Freiberg)Shiraz A. Shah(University of Copenhagen)Sita J. Saunders(TU Bergakademie Freiberg)Rodolphe Barrangou(North Carolina State University)Stan J. J. Brouns(Wageningen University & Research)Emmanuelle Charpentier(Helmholtz Centre for Infection Research)Daniel H. Haft(National Institutes of Health)Philippe Horvath(DuPont (France))Sylvain Moineau(Université Laval)Francisco J. M. Mojica(University of Alicante)Rebecca M. Terns(University of Georgia)Michael P. Terns(University of Georgia)Malcolm F. White(University of St Andrews)Alexander F. Yakunin(University of Toronto)Roger A. Garrett(University of Copenhagen)John van der Oost(Wageningen University & Research)Rolf Backofen(University of Freiburg)Eugene V. Koonin(National Institutes of Health)
CRISPR and Genetic EngineeringInsect symbiosis and bacterial influencesCytomegalovirus and herpesvirus researchCRISPRBiologyHorizontal gene transferComputational biologyGeneticsArchaeaLocus (genetics)Phylogenetic treeEvolutionary biologyAcquired immune system
MeSH terms
ArchaeaBacteriaPhylogenyGenome, BacterialEvolution, MolecularGenome, ArchaealCRISPR-Cas Systems
Funding
- Biotechnology and Biological Sciences Research Council
Citations
2,529
FWCI
107.26
field-weighted impact
References
118
Percentile
100%
vs. same field & year
Citations per year
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References
CRISPR-Cas systems for editing, regulating and targeting genomes
Nature Biotechnology · 2014 · 3,157 citations
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
Science · 2012 · 16,935 citations
The CRISPRdb database and tools to display CRISPRs and to generate dictionaries of spacers and repeats
BMC Bioinformatics · 2007 · 1,008 citations
Phage Response to CRISPR-Encoded Resistance in <i>Streptococcus thermophilus</i>
Journal of Bacteriology · 2007 · 1,239 citations
Short motif sequences determine the targets of the prokaryotic CRISPR defence system
Microbiology · 2009 · 1,550 citations
A Guild of 45 CRISPR-Associated (Cas) Protein Families and Multiple CRISPR/Cas Subtypes Exist in Prokaryotic Genomes
PLoS Computational Biology · 2005 · 979 citations
Evolution and classification of the CRISPR–Cas systems
Nature Reviews Microbiology · 2011 · 2,472 citations
Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin
Microbiology · 2005 · 1,710 citations
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