article Open AccessTop 1% cited

RNA virus interference via CRISPR/Cas13a system in plants

Genome biology · 2018 · Vol. 19(1) · pp. 1–1

Rashid Aman✉(King Abdullah University of Science and Technology)Zahir Ali(King Abdullah University of Science and Technology)Haroon Butt(King Abdullah University of Science and Technology)Ahmed Mahas(King Abdullah University of Science and Technology)Fatimah Aljedaani(King Abdullah University of Science and Technology)Muhammad Zuhaib Khan(King Abdullah University of Science and Technology)Shou‐Wei Ding(University of California, Riverside)Magdy M. Mahfouz(King Abdullah University of Science and Technology)

View via DOI Full-text PDF

Abstract

Our data indicate that CRISPR/Cas13a can be used for engineering interference against RNA viruses, providing a potential novel mechanism for RNA-guided immunity against RNA viruses and for other RNA manipulations in plants.

CRISPR and Genetic Engineering Plant Virus Research Studies Insect symbiosis and bacterial influencesCRISPRBiologyRNARNA interferenceNicotiana benthamianaRNA silencingCas9Trans-activating crRNAGeneticsComputational biology