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The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

Cell stem cell · 2011 · Vol. 8(5) · pp. 511–524

Anna Merlos‐Suárez(Institute for Research in Biomedicine)Francisco M. Barriga(Institute for Research in Biomedicine)Peter Jung(Institute for Research in Biomedicine)Mar Iglesias(Universitat Autònoma de Barcelona)María Virtudes Céspedes(Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine)David Rossell(Institute for Research in Biomedicine)Marta Sevillano(Institute for Research in Biomedicine)Xavier Hernando‐Momblona(Institute for Research in Biomedicine)Victoria da Silva-Diz(Institut d'Investigació Biomédica de Bellvitge)Purificacı́on Muñoz(Institut d'Investigació Biomédica de Bellvitge)Hans Clevers(University Medical Center Utrecht)Elena Sancho(Institute for Research in Biomedicine)Ramón Mangues(Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine)Eduard Batlle✉(Institute for Research in Biomedicine)

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Cancer Cells and Metastasis Cancer, Stress, Anesthesia, and Immune Response Digestive system and related healthBiologyStem cellColorectal cancerDiseaseCancer stem cellCancer researchSignature (topology)LGR5CancerCell

MeSH terms

AnimalsCell DifferentiationCell SeparationCells, CulturedColonic NeoplasmsFlow CytometryHumansIntestinesNeoplasm Recurrence, LocalPrognosisNeoplastic Stem CellsMice, KnockoutGene Expression Regulation, DevelopmentalGene Expression ProfilingCell Surface Extensions