articleTop 1% cited
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
Nature Cell Biology · 2010 · Vol. 12(5) · pp. 468–476
Louis Vermeulen✉(University of Amsterdam)Felipe de Sousa e Melo(University of Amsterdam)Maartje van der Heijden(University of Amsterdam)Kate Cameron(University of Amsterdam)Joan H. de Jong(University of Amsterdam)Tijana Borovski(University of Amsterdam)Jurriaan B. Tuynman(University of Amsterdam)Matilde Todaro(University of Palermo)Christian J. Merz(Apogenix (Germany))Hans M. Rodermond(Academic Medical Center)Martin R. Sprick(Academic Medical Center)Kristel Kemper(Academic Medical Center)Dick J. Richel(Academic Medical Center)Giorgio Stassi(University of Palermo)Jan Paul Medema(University of Amsterdam)
Cancer Cells and MetastasisWnt/β-catenin signaling in development and cancerGenetic factors in colorectal cancerWnt signaling pathwayStromal cellCancer stem cellBiologyCell biologyCancer researchTumor microenvironmentBeta-cateninStem cellPopulation
MeSH terms
AnimalsColonic NeoplasmsFibroblastsHumansMice, NudeNeoplasm ProteinsNeoplasms, ExperimentalTransplantation, HeterologousNeoplastic Stem CellsSignal TransductionHepatocyte Growth FactorCoculture TechniquesParacrine CommunicationWnt Proteinsbeta Catenin
Funding
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- China Scholarship Council
- Università degli Studi di Palermo
Citations
1,782
FWCI
57.69
field-weighted impact
References
48
Percentile
100%
vs. same field & year
Citations per year
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References
Wnt/β-catenin signaling in cancer stemness and malignant behavior
Current Opinion in Cell Biology · 2007 · 782 citations
Cancer Stem Cells—Perspectives on Current Status and Future Directions: AACR Workshop on Cancer Stem Cells
Cancer Research · 2006 · 3,057 citations
A genetic model for colorectal tumorigenesis
Cell · 1990 · 12,052 citations
The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells
Cell · 2008 · 8,672 citations
Genetic Alterations during Colorectal-Tumor Development
New England Journal of Medicine · 1988 · 6,737 citations
Wnt/β-Catenin Signaling in Development and Disease
Cell · 2006 · 5,519 citations
Colon Cancer Stem Cells Dictate Tumor Growth and Resist Cell Death by Production of Interleukin-4
Cell stem cell · 2007 · 1,036 citations
A Perivascular Niche for Brain Tumor Stem Cells
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