article Open AccessTop 1% cited
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo
Nature Immunology · 2009 · Vol. 10(9) · pp. 1000–1007
Xuyu Zhou✉(University of California, San Francisco)Samantha L. Bailey-Bucktrout(University of California, San Francisco)Lukas T. Jeker(University of California, San Francisco)Cristina Peñaranda(University of California, San Francisco)Marc Martínez‐Llordella(Hospital Clínic de Barcelona)Meredith Ashby(University of California, San Francisco)Maki Nakayama(University of Colorado Denver)Wendy Rosenthal(University of California, San Francisco)Jeffrey A. Bluestone(University of California, San Francisco)
T-cell and B-cell ImmunologyImmune Cell Function and InteractionAtherosclerosis and Cardiovascular DiseasesFOXP3BiologyCell biologyImmunologyAdoptive cell transferInterleukin 21ZAP70Immune systemIL-2 receptorNatural killer T cell
MeSH terms
Amino Acid SequenceAnimalsAutoimmune DiseasesHematopoietic Stem CellsImmunologic MemoryInterferon-gammaInterleukin-2Luminescent ProteinsMolecular Sequence DataReceptors, Antigen, T-CellImmunophenotypingMice, Inbred NODCpG IslandsDNA MethylationAdoptive Transfer
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References
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
Nature Genetics · 2001 · 3,333 citations
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide
Nature Immunology · 2001 · 1,632 citations
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
Nature Genetics · 2001 · 2,563 citations
Epigenetic Control of the foxp3 Locus in Regulatory T Cells
PLoS Biology · 2007 · 1,227 citations
DNA methylation controls <i>Foxp3</i> gene expression
European Journal of Immunology · 2008 · 760 citations
Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>
Science · 2003 · 8,062 citations
B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes
Immunity · 2000 · 2,031 citations
Foxp3<sup>+</sup>CD25<sup>+</sup>CD4<sup>+</sup> natural regulatory T cells in dominant self‐tolerance and autoimmune disease
Immunological Reviews · 2006 · 1,529 citations
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