reviewTop 1% cited
FOXP3+ regulatory T cells in the human immune system
Nature reviews. Immunology · 2010 · Vol. 10(7) · pp. 490–500
Shimon Sakaguchi✉(Kyoto University)Makoto Miyara(Osaka University)Cristina M. Costantino(Kyoto University)David A. Hafler(Kyoto University)
Immune Cell Function and InteractionT-cell and B-cell ImmunologyCytomegalovirus and herpesvirus researchFOXP3BiologyT cellPhenotypeImmune systemRegulatory T cellLineage (genetic)Cell biologyIL-2 receptorFunction (biology)
MeSH terms
AnimalsCell DifferentiationHumansImmunologic MemoryImmunotherapyPhenotypeT-Lymphocyte SubsetsLeukocyte Common AntigensSelf ToleranceModels, ImmunologicalT-Lymphocytes, RegulatoryMiceForkhead Transcription Factors
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References
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
Nature Genetics · 2001 · 3,333 citations
CD4+CD25high Regulatory Cells in Human Peripheral Blood
The Journal of Immunology · 2001 · 1,845 citations
Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells
Nature Immunology · 2010 · 5,839 citations
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
Nature Genetics · 2001 · 2,563 citations
Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans
Immunological Reviews · 2006 · 1,152 citations
Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level
European Journal of Immunology · 2005 · 586 citations
Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>
Science · 2003 · 8,062 citations
Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor
Immunity · 2009 · 2,233 citations
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