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B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes
Immunity · 2000 · Vol. 12(4) · pp. 431–440
Benoı̂t L. Salomon✉(University of Chicago)Deborah J. Lenschow(University of Chicago)Lesley Rhee(May Institute)Neda Ashourian(University of Chicago)Bhagirath Singh(Western University)Arlene H. Sharpe(Harvard University)J A Bluestone(May Institute)
T-cell and B-cell ImmunologyDiabetes and associated disordersImmune Cell Function and InteractionCD28NodNOD miceAutoimmunityIL-2 receptorImmunologyBiologyHomeostasisDiabetes mellitusType 1 diabetes
MeSH terms
AbataceptAnimalsAntigens, DifferentiationAutoimmune DiseasesDiabetes Mellitus, Type 1FemaleHomeostasisLymphocyte ActivationLymphokinesMaleMembrane GlycoproteinsPrediabetic StateReceptors, Interleukin-2CD4-Positive T-LymphocytesAntigens, CD
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References
CTLA-4 can function as a negative regulator of T cell activation
Immunity · 1994 · 2,184 citations
Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
Immunity · 1995 · 2,880 citations
CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production
The Journal of Experimental Medicine · 1998 · 2,598 citations
CD28/B7 SYSTEM OF T CELL COSTIMULATION
Annual Review of Immunology · 1996 · 2,714 citations
Thymus and Autoimmunity: Production of CD25+CD4+ Naturally Anergic and Suppressive T Cells as a Key Function of the Thymus in Maintaining Immunologic Self-Tolerance
The Journal of Immunology · 1999 · 1,196 citations
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