articleTop 1% cited
Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors
Journal of Pharmacology and Experimental Therapeutics · 2000 · Vol. 295(1) · pp. 139–145
Elisabeth Buchdunger✉(Novartis (Switzerland))Catherine L. Cioffi(Novartis (China))Norman M. Law(Novartis (China))David R. StoverSayuri Ohno-Jones(Oregon Health & Science University)Brian Druker(Cancer Institute (WIA))Nicholas Lydon(Novartis (China))
Chronic Myeloid Leukemia TreatmentsChronic Lymphocytic Leukemia ResearchMast cells and histaminePlatelet-derived growth factor receptorTyrosine kinaseReceptor tyrosine kinaseCancer researchProto-oncogene tyrosine-protein kinase SrcChronic myelogenous leukemiaAutophosphorylationROR1Growth factor receptorABL
MeSH terms
Imatinib MesylateAnimalsAntineoplastic AgentsBenzamidesCell LineEnzyme InhibitorsPiperazinesPyrimidinesSignal TransductionProto-Oncogene Proteins c-ablReceptors, Platelet-Derived Growth FactorProto-Oncogene Proteins c-kitStem Cell FactorMitogen-Activated Protein KinasesMice
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References
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr–Abl positive cells
Nature Medicine · 1996 · 3,643 citations
Potent and selective inhibitors of the Abl-kinase: phenylamino-pyrimidine (PAP) derivatives
Bioorganic & Medicinal Chemistry Letters · 1997 · 242 citations
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