articleTop 1% cited

A quantitative analysis of kinase inhibitor selectivity

Nature Biotechnology · 2008 · Vol. 26(1) · pp. 127–132

Computational Drug Discovery Methods Melanoma and MAPK Pathways Monoclonal and Polyclonal Antibodies ResearchKinomeSelectivityKinaseComputational biologyChemistryBiologyBiochemistry

Funding

Bristol-Myers Squibb

Citations

2,427

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253.44

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References

Discovery of <i>N</i>-(2-Chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a Dual Src/Abl Kinase Inhibitor with Potent Antitumor Activity in Preclinical Assays

Journal of Medicinal Chemistry · 2004 · 1,285 citations

The specificities of protein kinase inhibitors: an update

Biochemical Journal · 2003 · 1,355 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

FEBS Letters · 1995 · 2,089 citations

The Protein Kinase Complement of the Human Genome

Science · 2002 · 8,071 citations

Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition

Nature Structural & Molecular Biology · 2004 · 614 citations

A Unique Structure for Epidermal Growth Factor Receptor Bound to GW572016 (Lapatinib)

Cancer Research · 2004 · 1,108 citations

BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis

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Abl Protein-Tyrosine Kinase Inhibitor STI571 Inhibits In Vitro Signal Transduction Mediated by c-Kit and Platelet-Derived Growth Factor Receptors

Journal of Pharmacology and Experimental Therapeutics · 2000 · 1,280 citations

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