article Open AccessTop 1% cited
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
Nature Medicine · 2011 · Vol. 17(2) · pp. 179–188
Bolormaa Vandanmagsar✉(Louisiana State University)Yun‐Hee Youm(Louisiana State University)Anthony Ravussin(Louisiana State University)José E. Galgani(Pennington Biomedical Research Center)Krisztián Stadler(Louisiana State University)Randall L. Mynatt(Louisiana State University)Éric Ravussin(Louisiana State University)Jacqueline M. Stephens(Louisiana State University System)Vishwa Deep Dixit(Pennington Biomedical Research Center)
Inflammasome and immune disordersAdipokines, Inflammation, and Metabolic DiseasesIL-33, ST2, and ILC PathwaysInflammasomeAdipose tissueInsulin resistanceInflammationPyrin domainEndocrinologyInternal medicineLipotoxicityCaspase 1Biology
MeSH terms
NLR Family, Pyrin Domain-Containing 3 ProteinAdipose TissueAnimalsCarrier ProteinsDisease Models, AnimalFemaleGlucose Tolerance TestHumansInflammationInsulinInsulin ResistanceMacrophagesMaleMice, Inbred C57BLObesity
Funding
- University of Louisville
- Genentech
Citations
2,548
FWCI
63.75
field-weighted impact
References
63
Percentile
100%
vs. same field & year
Citations per year
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References
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Molecular Cell · 2002 · 5,936 citations
The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis
Nature Immunology · 2009 · 1,825 citations
Inflammation and metabolic disorders
Nature · 2006 · 8,779 citations
Obesity is associated with macrophage accumulation in adipose tissue
Journal of Clinical Investigation · 2003 · 8,580 citations
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
Nature Immunology · 2009 · 2,599 citations
A Proposed Classification of the Immunological Diseases
PLoS Medicine · 2006 · 803 citations
Inflammasome Components NALP 1 and 3 Show Distinct but Separate Expression Profiles in Human Tissues Suggesting a Site-specific Role in the Inflammatory Response
Journal of Histochemistry & Cytochemistry · 2006 · 529 citations
Adipocyte Death, Adipose Tissue Remodeling, and Obesity Complications
Diabetes · 2007 · 973 citations
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