articleTop 1% cited
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
Nature Immunology · 2006 · Vol. 8(2) · pp. 191–197
Jeong Kim✉(University of Washington)Jeffrey P. Rasmussen(University of Washington)Alexander Y. Rudensky(University of Washington)
T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune Cell Function and InteractionFOXP3BiologyCell biologyImmunologyIL-2 receptorCytotoxic T cellInterleukin 21AutoimmunityNatural killer T cellZAP70
MeSH terms
AgingAnimalsAnimals, NewbornDendritic CellsKineticsLymphocyte ActivationMice, Inbred C57BLAutoimmunitySelf ToleranceT-Lymphocytes, RegulatoryMiceForkhead Transcription Factors
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References
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
Nature Genetics · 2001 · 3,333 citations
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide
Nature Immunology · 2001 · 1,632 citations
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
Nature Genetics · 2001 · 2,563 citations
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Science · 2003 · 8,062 citations
An essential role for Scurfin in CD4+CD25+ T regulatory cells
Nature Immunology · 2003 · 2,816 citations
CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells
European Journal of Immunology · 2000 · 580 citations
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
Nature Immunology · 2003 · 7,605 citations
Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor <i>Foxp3 </i>
The Journal of Experimental Medicine · 2003 · 4,596 citations
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