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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
Nature Immunology · 2003 · Vol. 4(4) · pp. 330–336
T-cell and B-cell ImmunologyImmune Cell Function and InteractionImmunotherapy and Immune ResponsesFOXP3IL-2 receptorRegulatory T cellCell biologyBiologyTranscription factorAutoimmunityT cellImmunologyImmune system
MeSH terms
AnimalsDNA-Binding ProteinsFemaleReceptors, Interleukin-2CD4-Positive T-LymphocytesDown-RegulationGene TargetingMiceForkhead Transcription Factors
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N<scp>aturally</scp>A<scp>rising</scp>CD4<sup>+</sup>R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>
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References
The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
Nature Genetics · 2001 · 3,333 citations
CD4+CD25+ suppressor T cells: more questions than answers
Nature reviews. Immunology · 2002 · 2,106 citations
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide
Nature Immunology · 2001 · 1,632 citations
Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells
Nature Immunology · 2010 · 5,839 citations
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
Nature Genetics · 2001 · 2,563 citations
Immunologic tolerance maintained by CD25<sup>+</sup> CD4<sup>+</sup> regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance
Immunological Reviews · 2001 · 1,512 citations
An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation
The Journal of Experimental Medicine · 1999 · 1,584 citations
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
The Journal of Immunology · 1995 · 5,432 citations
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