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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Nature Genetics · 2010 · Vol. 42(11) · pp. 937–948

MAGIC(Broad Institute)Elizabeth K. Speliotes(Broad Institute)Cristen J. Willer(National Institutes of Health)Sonja I. Berndt(University of North Carolina at Chapel Hill)Keri L. Monda(deCODE Genetics (Iceland))Guðmar Þorleifsson(University of Michigan)Anne Jackson(University of Exeter)Hana Lango Allen(Centre for Human Genetics)Cecilia M. Lindgren(Addenbrooke's Hospital)Jian’an Luan(Centre for Human Genetics)Reedik Mägi(Centre for Human Genetics)Joshua C. Randall(Broad Institute)Sailaja VedantamThomas W. Winkler(Brigham and Women's Hospital)Lu Qi(Harvard University)Tsegaselassie WorkalemahuIris M. Heid(deCODE Genetics (Iceland))Valgerður Steinthórsdóttir(University of Michigan)Heather M. Stringham(University of Exeter)Michael N. Weedon(Wellcome Sanger Institute)Eleanor Wheeler(University of Exeter)Andrew R. Wood(Centre for Human Genetics)Teresa Ferreira(University of Michigan)Robert J. Weyant(Broad Institute)Ayellet V. Segrè(Erasmus MC)Karol Estrada(Harvard University)Liming Liang(Broad Institute)James Nemesh(National Institutes of Health)Ju-Hyun Park(Karolinska Institutet)Stefan Gustafsson(Addenbrooke's Hospital)Tuomas O. Kilpeläinen(QIMR Berghofer Medical Research Institute)Jian Yang(Centre National de la Recherche Scientifique)Nabila Bouatia‐Naji(Estonian Biocentre)Tōnu Esko(Washington University in St. Louis)Mary F. Feitosa(SIB Swiss Institute of Bioinformatics)Zoltán Kutalik(King's College London)Massimo Mangino(Broad Institute)Soumya Raychaudhuri(University of Duisburg-Essen)André Scherag(University of Iceland)Albert V. Smith(University of Michigan)Ryan Welch(Addenbrooke's Hospital)Wei Zhao(Netherlands Comprehensive Cancer Organisation)Katja K.H. Aben(HudsonAlpha Institute for Biotechnology)Devin M. Absher(Erasmus MC)Najaf Amin(University of Bath)Anna Dixon(German Institute of Human Nutrition)Eva Fisher(University of Washington)Nicole L. Glazer(The University of Melbourne)Michael E. Goddard(Boston University)Nancy L. Heard‐Costa(Technical University of Munich)Volker Hoesel(Vrije Universiteit Amsterdam)Jouke‐Jan Hottenga(Uppsala University)Åsa Johansson(SIB Swiss Institute of Bioinformatics)Toby Johnson(Washington University in St. Louis)Shamika Ketkar(Helmholtz Zentrum München)Claudia Lamina(Addenbrooke's Hospital)Shengxu Li(Imperial College London)Miriam F. Moffatt(Boston University)Richard H. Myers(National Institutes of Health)Narisu Narisu(University of Exeter)John R. B. Perry(Erasmus MC)Marjolein J. Peters(University Hospital Schleswig-Holstein)Michael Preuß(University of Helsinki)Samuli Ripatti(Erasmus MC)Fernando RivadeneiraCamilla H. Sandholt(University of Michigan)Laura J. ScottNicholas J. Timpson(University of Cambridge)Jonathan P. Tyrer(Erasmus MC)S. van Wingerden(University of Southern California)Richard M. Watanabe(Boston University)Charles C. White(Karolinska Institutet)Fredrik Wiklund(University of Milan)Cristina Barlassina(Brigham and Women's Hospital)Daniel I. Chasman(The University of Western Australia)Matthew N. Cooper(University of Gothenburg)John‐Olov Jansson(The University of Western Australia)Robert Lawrence(University of Helsinki)Niina Pellikka(Centre for Human Genetics)Inga Prokopenko(National Institutes of Health)Jianxin Shi(Helmholtz Zentrum München)Elisabeth Thiering(University of Tartu)Helene Alavere(Vita-Salute San Raffaele University)Maria Teresa Sciarrone Alibrandi(Lund University)Peter Almgren(University of Washington)Alice M. Arnold(Icelandic Heart Association)Thor Aspelund(Boston University)Larry D. Atwood(Inserm)Beverley Balkau(University of Leeds)Anthony J. Balmforth(University of Oxford)Amanda J. Bennett(University of Bristol)Yoav Ben‐Shlomo(University of Southern California)Richard N. Bergman(University of Lausanne)Sven Bergmann(Charité - Universitätsmedizin Berlin)Heike Biebermann(Genomics (United Kingdom))Alexandra I. F. Blakemore(University of Duisburg-Essen)Tanja Boes(National Institutes of Health)Lori L. Bonnycastle(Technische Universität Dresden)Stefan R. Bornstein(University of Cambridge)Matthew A. Brown(University of Southern California)Thomas A. Buchanan(Institute of Genetic and Biomedical Research)Fabio Busonero(University of Edinburgh)Harry Campbell(University of Warwick)Francesco P. Cappuccio(Centre National de la Recherche Scientifique)Christine Cavalcanti-Proença(Cedars-Sinai Medical Center)Yii‐Der Ida Chen(Helmholtz Zentrum München)Chih‐Mei Chen(National Institutes of Health)Peter S. Chines(MRC Clinical Trials Unit at UCL)Robert Clarke(Imperial College London)Lachlan Coin(University of Dundee)John ConnellIan N.M. Day(Radboud University Nijmegen)Martin den Heijer(NorthShore University HealthSystem)Jubao Duan(London School of Hygiene & Tropical Medicine)Shah Ebrahim(Imperial College London)Paul Elliott(Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)Roberto Elosúa(Icelandic Heart Association)Guðný Eiríksdóttir(National Institutes of Health)Michael R. Erdos(University of Helsinki)Johan G. Eriksson(Eurac Research)Maurizio Facheris(Universität Greifswald)Stephan B. FelixPamela Fischer‐Posovszky(University of Minnesota)Aaron R. FolsomNele Friedrich(University of California, Los Angeles)Nelson B. Freimer(University of Maryland, Baltimore)Mao Fu(Centre National de la Recherche Scientifique)Stefan Gaget(NorthShore University HealthSystem)Pablo V. Gejman(Vrije Universiteit Amsterdam)Eco J. C. de Geus(Helmholtz Zentrum München)Christian GiegerAnette P. Gjesing(Centre for Human Genetics)Anuj Goel(Montreal Heart Institute)Philippe Goyette(Helmholtz Zentrum München)Harald Grallert(Technische Universität Dresden)Jürgen Gräßler(Merck & Co., Inc., Rahway, NJ, USA (United States))Danielle M. Greenawalt(University of Oxford)Christopher J. Groves(University of Iceland)Vilmundur Guðnason(Broad Institute)Candace Guiducci(University of Oulu)Anna‐Liisa Hartikainen(University of Oxford)Neelam Hassanali(University of Leeds)Alistair S. Hall(Finnish Institute for Health and Welfare)Aki S. Havulinna(Western General Hospital)Caroline Hayward(Washington University in St. Louis)Andrew C. Heath(University Hospital Regensburg)Christian Hengstenberg(Eurac Research)Andrew A. Hicks(University of Duisburg-Essen)Anke Hinney(Erasmus MC)Albert Hofman(Universität Greifswald)Georg Homuth(The University of Western Australia)Jennie Hui(Uppsala University)Wilmar Igl(Kaiser Permanente)Carlos Iribarren(Folkhälsans Forskningscentrum)Bo Isomaa(National Cancer Institute)Kevin B. Jacobs(Philipps University of Marburg)Ivonne Jarick(University of Michigan)Elizabeth S. Jewell(Universitätsmedizin Greifswald)Ulrich John(University of Copenhagen)Torben Jørgensen(Finnish Institute for Health and Welfare)Pekka Jousilahti(Finnish Institute for Health and Welfare)Antti Jula(University of Oulu)Marika Kaakinen(Finnish Institute for Health and Welfare)Eero Kajantie(Harvard University)Lee M. Kaplan(Broad Institute)Sekar Kathiresan(University of Helsinki)Johannes Kettunen(Finnish Institute for Health and Welfare)Leena Kinnunen(Stanford University)Joshua W. Knowles(University of Zagreb)Ivana Kolčić(University Hospital Schleswig-Holstein)Inke R. König(Finnish Institute for Health and Welfare)Seppo KoskinenPéter Kovács(Kuopio University Hospital)Johanna Kuusisto(Harvard University)Peter Kraft(Norwegian University of Science and Technology)Kirsti Kvaløy(Finnish Institute of Occupational Health)Jaana Laitinen(Institut de Recherche en Santé, Environnement et Travail)Olivier Lantieri(Vita-Salute San Raffaele University)Chiara Lanzani(National Institutes of Health)Lenore J. Launer(Centre National de la Recherche Scientifique)Cécile Lecœur(Tampere University Hospital)Terho Lehtimäki(Montreal Heart Institute)Guillaume Lettre(Genome Institute of Singapore)Jianjun Liu(University of Helsinki)Marja‐Liisa Lokki(University of Gothenburg)Mattias Lorentzon(University of Cambridge)Robert Luben(Technische Universität Dresden)Barbara Ludwig(Vita-Salute San Raffaele University)Paolo Manunta(SIB Swiss Institute of Bioinformatics)Diana Marek(Université Claude Bernard Lyon 1)Michel Marre(QIMR Berghofer Medical Research Institute)Nicholas G. Martin(University of Bristol)Wendy L. McArdle(Health Research Board)Anne McCarthy(University of Washington)Barbara McKnight(TUM Klinikum)Thomas Meitinger(Lund University)Olle Melander(Centre National de la Recherche Scientifique)Stephen Eyre(Norwegian University of Science and Technology)Kristian Midthjell(QIMR Berghofer Medical Research Institute)Grant W. Montgomery(National Institutes of Health)Mario A. Morken(Centre for Human Genetics)Andrew P. Morris(University of Split)Rosanda Mulić(Boston University)Julius S. Ngwa(Estonian Biocentre)Mari Nelis(University of Oxford)Matt J. Neville(QIMR Berghofer Medical Research Institute)Dale R. Nyholt(National Heart Lung and Blood Institute)Christopher J. O’Donnell(University of Cambridge)Stephen O’Rahilly(Addenbrooke's Hospital)Ken K. Ong(Erasmus MC)Ben A. Oostra(McMaster University)Guillaume Paré(Amgen (United States))Alex Parker(University of Helsinki)Markus Perola(Eurac Research)Irene Pichler(University of Helsinki)Kirsi H. Pietiläinen(Norwegian University of Science and Technology)Carl G. P. Platou(University of Zagreb)Ozren Polašek(University of Oulu)Anneli Pouta(University of Leicester)Suzanne Rafelt(University of Turku)Olli T. Raitakari(Centre for Human Genetics)Nigel W. Rayner(Lund University)Martin Ridderstråle(Philipps University of Marburg)Winfried Rief(University of Oulu)Aimo Ruokonen(Centre for Human Genetics)Neil R. Robertson(Helmholtz Zentrum München)Peter Rzehak(Finnish Institute for Health and Welfare)Veikko Salomaa(NorthShore University HealthSystem)Alan R. Sanders(University of Cambridge)Manjinder S. Sandhu(Institute of Genetic and Biomedical Research)Serena Sanna(South Karelia Central Hospital)Jouko Saramies(University of Oulu)Markku J. Savolainen(University of Duisburg-Essen)Susann ScheragSabine Schipf(Christian-Albrechts-Universität zu Kiel)Stefan Schreiber(University of Lübeck)Heribert Schunkert(University of Helsinki)Kaisa Silander(Helsinki University Hospital)Juha Sinisalo(University of Washington)David S. Siscovick(Amsterdam Public Health)Jan Smit(King's College London)Nicole Soranzo(Imperial College London)Ulla Sovio(National Health Service)Jonathan Stephens(Finnish Institute for Health and Welfare)Ida Surakka(National Institutes of Health)Amy J. Swift(University of Tartu)Mari‐Liis Tammesoo(Montreal Heart Institute)Jean‐Claude Tardif(Estonian Biocentre)Maris Teder‐Laving(University of Michigan)Tanya M. Teslovich(Glenfield Hospital)John R. Thompson(Broad Institute)Brian Thomson(Leipzig University)Anke Tönjes(Folkhälsans Forskningscentrum)Tiinamaija Tuomi(Erasmus MC)Joyce B. J. van Meurs(Leiden University Medical Center)Gert‐Jan B. van Ommen(Centre National de la Recherche Scientifique)Vincent Vatin(University of Turku)Jorma Viikari(Inserm)Sophie Visvikis‐Siest(Western General Hospital)Véronique Vitart(University of Duisburg-Essen)Carla Ivane Ganz Vogel(Broad Institute)Benjamin F. Voight(HudsonAlpha Institute for Biotechnology)Lindsay L. WaiteHenri Wallaschofski(deCODE Genetics (Iceland))G. Bragi Walters(University of Helsinki)Elisabeth Widén(Charité - Universitätsmedizin Berlin)Susanna Wiegand(University of Edinburgh)Sarah H. Wild(Vrije Universiteit Amsterdam)Gonneke Willemsen(Steno Diabetes Centers)Daniel R. Witte(Erasmus MC)Jacqueline C.M. Witteman(Wake Forest University)Jianfeng Xu(Washington University in St. Louis)Qunyuan Zhang(University of Zagreb)Lina Zgaga(University Hospital Schleswig-Holstein)Andreas Ziegler(Lapland Central Hospital)Paavo Zitting(Sir Charles Gairdner Hospital)John Beilby(University of Cambridge)I. Sadaf Farooqi(University of Duisburg-Essen)Johannes Hebebrand(University of Oulu)Heikki Huikuri(Sir Charles Gairdner Hospital)Anthony James(Tampere University Hospital)Mika Kähönen(Stanford University)Douglas F. Levinson(University of Milan)Fabìo Macciardi(Helsinki University Hospital)Markku S. Nieminen(University of Gothenburg)Claes Ohlsson(The University of Western Australia)Lyle J. Palmer(Brigham and Women's Hospital)Paul M. Ridker(Leipzig University)Michael Stümvoll(University Hospital of Lausanne)J. Beckmann(German Institute of Human Nutrition)Heiner Boeing(The University of Texas Health Science Center at Houston)Eric Boerwinkle(Vrije Universiteit Amsterdam)Dorret I. Boomsma(Queen Mary University of London)Mark J. Caulfield(National Institutes of Health)Stephen J. Chanock(National Institutes of Health)Francis S. Collins(Boston University)L. Adrienne CupplesGeorge Davey Smith(University of Lübeck)Jeanette Erdmann(Centre National de la Recherche Scientifique)Philippe Froguel(Karolinska Institutet)Henrik Grönberg(Uppsala University)Ulf Gyllensten(Karolinska Institutet)Per HallTorben Hansen(National Institutes of Health)Tamara B. Harris(University of Exeter)Andrew T. Hattersley(Columbia University Irving Medical Center)Richard B. Hayes(Helmholtz Zentrum München)Joachim Heinrich(Brigham and Women's Hospital)Frank B. Hu(Norwegian University of Science and Technology)Kristian Hveem(Helmholtz Zentrum München)Thomas Illig(Finnish Institute for Health and Welfare)Marjo‐Riitta Järvelin(University of Helsinki)Jaakko Kaprio(Churchill Hospital)Fredrik Karpe(University of Cambridge)Kay‐Tee Khaw(Radboud University Nijmegen)Lambertus A. Kiemeney(Charité - Universitätsmedizin Berlin)Heiko Krude(Kuopio University Hospital)Markku LaaksoDebbie A. Lawlor(Estonian Biocentre)Andres Metspalu(Queen Mary University of London)Patricia B. Munroe(National Health Service)Willem H. Ouwehand(University of Copenhagen)Oluf Pedersen(Amsterdam Public Health)Brenda W.J.H. Penninx(Helmholtz Zentrum München)Annette Peters(Eurac Research)Peter P. Pramstaller(Stanford University)Thomas Quertermous(Witten/Herdecke University)Thomas Reinehr(Helsinki University Hospital)Aila Rissanen(University of Split)Igor Rudan(University of Leicester)Nilesh J. Samani(Technische Universität Dresden)Peter Schwarz(University of Maryland, Baltimore)Alan R. Shuldiner(King's College London)Timothy D. Spector(Finnish Institute for Health and Welfare)Jaakko Tuomilehto(Institute of Genetic and Biomedical Research)Manuela Uda(Netherlands Consortium for Healthy Ageing)André G. Uitterlinden(Finnish Institute for Health and Welfare)Timo T. ValleMartin Wabitsch(University Hospital of Lausanne)Gérard Waeber(Addenbrooke's Hospital)Nicholas J. Wareham(John Radcliffe Hospital)Hugh Watkins(University of Edinburgh)James F. Wilson(Western General Hospital)Alan F. Wright(Netherlands Consortium for Healthy Ageing)M. Carola Zillikens(National Institutes of Health)Nilanjan Chatterjee(Broad Institute)Steven A. McCarroll(Broad Institute)Shaun Purcell(Sage Bionetworks)Eric E. Schadt(QIMR Berghofer Medical Research Institute)Peter M. Visscher(Stanford University)Themistocles L. Assimes(Washington University in St. Louis)Ingrid B. Borecki(Wellcome Sanger Institute)Panos Deloukas(National Heart Lung and Blood Institute)Caroline S. Fox(Lund University)Leif Groop(Cedars-Sinai Medical Center)Talin Haritunians(Brigham and Women's Hospital)David J. Hunter(Albert Einstein College of Medicine)Robert C. Kaplan(University of North Carolina at Chapel Hill)Karen L. Mohlke(University of Maryland, Baltimore)Jeffrey R. O’Connell(University of Helsinki)Leena Peltonen(National Institute on Aging)David Schlessinger(St George's, University of London)David P. Strachan(Erasmus MC)Cornelia M. van Duijn(LMU Klinikum)H‐Erich Wichmann(University of Exeter)Timothy M. Frayling(University of Iceland)Unnur Þorsteinsdóttir(University of Michigan)Gonçalo R. Abecasis(University of Cambridge)Inês Barroso(University of Michigan)Michael Boehnke(deCODE Genetics (Iceland))Kāri Stefánsson✉(University of North Carolina at Chapel Hill)Kari E. North(Centre for Human Genetics)Mark I. McCarthy✉(Harvard University)Joel N. Hirschhorn(Karolinska Institutet)Erik Ingelsson(Addenbrooke's Hospital)Ruth J. F. Loos

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Regulation of Appetite and Obesity Genetic Associations and Epidemiology Biochemical Analysis and Sensing TechniquesBiologyBody mass indexGeneticsGenome-wide association studySingle-nucleotide polymorphismObesityGenetic associationQuantitative trait locusSNPGene

MeSH terms

Body HeightBody WeightChromosome MappingHumansObesityBody Mass IndexGenetic Predisposition to DiseasePolymorphism, Single NucleotideWhite PeopleBody SizeGenome-Wide Association Study