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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Nature Genetics · 2010 · Vol. 42(2) · pp. 105–116

Josée Dupuis✉(Boston University)the MAGIC investigators(Addenbrooke's Hospital)Claudia Langenberg(University of Oxford)Inga Prokopenko(Broad Institute)Richa Saxena(Wellcome Sanger Institute)Nicole Soranzo(University of Michigan)Anne Jackson(Wellcome Sanger Institute)Eleanor Wheeler(University of Washington)Nicole L. Glazer(Institut Pasteur de Lille)Nabila Bouatia‐Naji(University of Oxford)Anna L. Gloyn(University of Oxford)Cecilia M. Lindgren(University of Oxford)Reedik Mägi(Centre for Human Genetics)Andrew P. Morris(Centre for Human Genetics)Joshua C. Randall(University of Lausanne)Toby Johnson(Imperial College London)Paul Elliott(Boston University)Denis Rybin(deCODE Genetics (Iceland))Guðmar Þorleifsson(deCODE Genetics (Iceland))Valgerður Steinthórsdóttir(Leiden University)Peter Henneman(Helmholtz Zentrum München)Harald GrallertAbbas Dehghan(Vrije Universiteit Amsterdam)Jouke‐Jan Hottenga(University of Edinburgh)C. Franklin(Institute of Genetics and Cancer)Pau Navarro(GlaxoSmithKline (United States))Kijoung Song(Centre for Human Genetics)Anuj Goel(University of Exeter)John R. B. Perry(National Institute on Aging)Josephine M. Egan(University of Oulu)Taina K. LajunenNiels GrarupThomas Sparsø(Ninewells Hospital)Alex S. F. Doney(Broad Institute)Benjamin F. Voight(University of Michigan)Heather M. Stringham(Broad Institute)Man Li(Harokopio University of Athens)Stavroula Kanoni(Massachusetts General Hospital)Peter Shrader(Institut Pasteur de Lille)Christine Cavalcanti-Proença(University College London)Meena Kumari(Harvard University)Lu Qi(University of Bristol)Nicholas J. Timpson(Helmholtz Zentrum München)Christian Gieger(Hospital Clínico San Carlos)Katja K.H. Aben(McGill University)Ghislain Rocheleau(Karolinska Institutet)Erik Ingelsson(Washington University in St. Louis)Ping An(University of Maryland, Baltimore)Jeffrey R. O’Connell(Addenbrooke's Hospital)Jian’an Luan(Massachusetts General Hospital)Amanda Elliott(Massachusetts General Hospital)Steven A. McCarroll(Wellcome Sanger Institute)Felicity Payne(Wellcome Sanger Institute)Rosa Maria Roccasecca(Inserm)François Pattou(National Human Genome Research Institute)Praveen Sethupathy(Broad Institute)Kristin Ardlie(Leiden University Medical Center)Yavuz Ariyürek(Université Paris-Sud)Beverley Balkau(The Heart Research Institute)Philip J. Barter(Queen Elizabeth II Medical Centre)John Beilby(University of Bristol)Yoav Ben‐Shlomo(Reykjavík University)Rafn Benediktsson(University of Oxford)Amanda J. Bennett(University of Lausanne)Richard N. Bergman(University Hospital of Lausanne)Murielle Bochud(The University of Texas Health Science Center at Houston)Eric Boerwinkle(Institut Pasteur de Lille)Amélie Bonnefond(National Human Genome Research Institute)Lori L. Bonnycastle(Steno Diabetes Centers)Knut Borch‐Johnsen(Leipzig University)Yvonne Böttcher(University College London)Eric J. Brunner(Wellcome Sanger Institute)Suzannah J. BumpsteadG. Charpentier(Cedars-Sinai Medical Center)Yii‐Der Ida Chen(National Human Genome Research Institute)Peter S. Chines(University of Oxford)Robert Clarke(Imperial College London)Lachlan Coin(The University of Western Australia)Matthew N. Cooper(Harvard University)Marilyn C. Cornelis(Broad Institute)Gabe Crawford(Institute of Genetic and Biomedical Research)Laura Crisponi(University of Bristol)Ian N.M. Day(Vrije Universiteit Amsterdam)Eco J. C. de Geus(Institut Pasteur de Lille)Jérôme Delplanque(Institut Pasteur de Lille)Christian Dina(National Human Genome Research Institute)Michael R. Erdos(The University of Western Australia)Annette C. Fedson(Charité - Universitätsmedizin Berlin)Antje Fischer-Rosinský(Addenbrooke's Hospital)Nita G. Forouhi(National Heart Lung and Blood Institute)Caroline S. Fox(Leiden University)Rune R. Frants(Mario Negri Institute for Pharmacological Research)Maria Grazia Franzosi(Inserm)Pilar Galán(Cedars-Sinai Medical Center)Mark O. Goodarzi(Technische Universität Dresden)J. Graessler(University of Oxford)Christopher J. Groves(HumanN (United States))Scott M. Grundy(Wellcome Sanger Institute)Rhian Gwilliam(Uppsala University)Ulf Gyllensten(Inserm)Samy Hadjadj(Umeå University)Göran Hallmans(Wellcome Sanger Institute)Naomi Hammond(University of Michigan)Xijing Han(University of Oulu)Anna‐Liisa Hartikainen(University of Oxford)Neelam Hassanali(Institute of Genetics and Cancer)Caroline HaywardSimon Heath(Délégation Paris 5)Serge Herçberg(Deutsches Diabetes-Zentrum e.V.)Christian Herder(Eurac Research)Andrew A. Hicks(West Australian Sleep Disorders Research Institute)David R. Hillman(University College London)Aroon D. HingoraniAlbert Hofman(Queen Elizabeth II Medical Centre)Jennie Hui(Sir Charles Gairdner Hospital)Joseph Hung(Folkhälsans Forskningscentrum)Bo Isomaa(University of Oxford)Paul R V Johnson(Glostrup Hospital)Torben Jørgensen(Finnish Institute for Health and Welfare)Antti Jula(University of Oulu)Marika Kaakinen(University of Helsinki)Jaakko Kaprio(Biocenter Finland)Y. Antero Kesäniemi(University College London)Mika Kivimäki(University of Exeter)Beatrice Knight(Finnish Institute for Health and Welfare)Seppo KoskinenPéter Kovács(University of Southern Denmark)Kirsten Ohm KyvikG.M. Lathrop(University of Bristol)Debbie A. Lawlor(Institut Pasteur de Lille)Olivier Le Bacquer(Institut Pasteur de Lille)Cécile Lecœur(University of Michigan)Yun Li(Lund University)Valeriya Lyssenko(Gladstone Institutes)Robert W. Mahley(St Thomas' Hospital)Massimo Mangino(Boston University)Alisa K Manning(Hospital Clínico San Carlos)Nicholas G. Martin(Broad Institute)Jarred B. McAteer(University of Oxford)Laura McCulloch(University of Ottawa)Ruth McPherson(Helmholtz Zentrum München)Christa Meisinger(University of Exeter)David Melzer(Institut Pasteur de Lille)Stephen Eyre(University of Maryland, Baltimore)Braxton D. Mitchell(National Human Genome Research Institute)Mario A. Morken(West Australian Sleep Disorders Research Institute)Sutapa Mukherjee(Institute of Genetic and Biomedical Research)Silvia Naitza(National Human Genome Research Institute)Narisu Narisu(University of Oxford)Matthew NevilleBen A. Oostra(Institute of Genetic and Biomedical Research)Marco Orrù(University of Maryland, Baltimore)Ruth Pakyz(University of Dundee)Colin N A Palmer(University of Campania "Luigi Vanvitelli")Giuseppe Paolisso(Eurac Research)Cristian Pattaro(National Human Genome Research Institute)Daniel S. Pearson(University of Oxford)John F. Peden(Karolinska Institutet)Nancy L. Pedersen(University of Helsinki)Markus Perola(Charité - Universitätsmedizin Berlin)Andreas Pfeiffer(Eurac Research)Irene Pichler(University of Zagreb)Ozren Polašek(Vrije Universiteit Amsterdam)Daniëlle Posthuma(Wellcome Sanger Institute)Simon Potter(Oulu University Hospital)Anneli Pouta(Washington University in St. Louis)Michael A. Province(University of Washington)Bruce M. Psaty(Deutsches Diabetes-Zentrum e.V.)Wolfgang Rathmann(Centre for Human Genetics)Nigel W. Rayner(University of Washington)Kenneth Rice(University of Helsinki)Samuli RipattiFernando Rivadeneira(Deutsches Diabetes-Zentrum e.V.)Michael Roden(Umeå University)Olov Rolandsson(Aarhus University)Annelli Sandbæk(University of Cambridge)Manjinder S. Sandhu(Institute of Genetic and Biomedical Research)Serena Sanna(Southampton General Hospital)Avan Aihie Sayer(The University of Texas MD Anderson Cancer Center)Paul Scheet(University of Michigan)Laura J. Scott(University of Münster)Udo Seedorf(Addenbrooke's Hospital)Stephen J. Sharp(University of Exeter)Beverley M. Shields(Reykjavík University)Gunnar SigurðssonEric J.G. Sijbrands(Karolinska Institutet)Angela Silveira(The University of Western Australia)Laila Simpson(National Institute on Aging)Andrew B. Singleton(University of Washington)Nicholas L. Smith(Imperial College London)Ulla Sovio(National Human Genome Research Institute)Amy J. Swift(Southampton General Hospital)Holly Syddall(Uppsala University)Ann‐Christine Syvänen(MedStar Health)Toshiko Tanaka(Helmholtz Zentrum München)Barbara ThorandJean Tichet(Leipzig University)Anke Tönjes(Folkhälsans Forskningscentrum)Tiinamaija TuomiAndré G. Uitterlinden(Leiden University)Ko Willems van DijkMandy van Hoek(Wellcome Sanger Institute)Dhiraj Varma(Université de Lorraine)Sophie Visvikis‐Siest(Institute of Genetics and Cancer)Véronique Vitart(Amsterdam Public Health)Nicole Vogelzangs(University Hospital of Lausanne)Gérard Waeber(University of Helsinki)Peter J. Wagner(Hammersmith Hospital)Andrew J. Walley(deCODE Genetics (Iceland))G. Bragi Walters(The University of Western Australia)Kim L Ward(University of Oxford)Hugh Watkins(University of Exeter)Michael N. Weedon(University of Edinburgh)Sarah H. Wild(Vrije Universiteit Amsterdam)Gonneke WillemsenJ. C. M. Witteman(Queen's University Belfast)J. W. G. Yarnell(Wellcome Sanger Institute)Eleftheria ZegginiDiana Zélénika(Uppsala University)Björn Zethelius(St Thomas' Hospital)Guangju Zhai(Addenbrooke's Hospital)Wei ZhaoM. Carola Zillikens(Washington University in St. Louis)Ingrid B. Borecki(Addenbrooke's Hospital)Ruth J. F. Loos(Délégation Paris 5)Pierre Meneton(Karolinska Institutet)Patrik K. E. Magnusson(Massachusetts General Hospital)David M. Nathan(Brigham and Women's Hospital)Gordon H. Williams(University of Exeter)Andrew T. Hattersley(University of Helsinki)Kaisa Silander(Finnish Institute for Health and Welfare)Veikko Salomaa(University of Bristol)George Davey Smith(Technische Universität Dresden)Stefan R. Bornstein(Technische Universität Dresden)Peter E. H. Schwarz(Charité - Universitätsmedizin Berlin)Joachim Spranger(Churchill Hospital)Fredrik Karpe(University of Maryland, Baltimore)Alan R. Shuldiner(Southampton General Hospital)Cyrus Cooper(Harokopio University of Athens)George Dedoussis(Hospital Clínico San Carlos)Manuel Serrano‐Ríos(University of Dundee)Andrew D. Morris(Uppsala University)Lars Lind(West Australian Sleep Disorders Research Institute)Lyle J. Palmer(Harvard University)Frank B. Hu(Umeå University)Paul W. Franks(London School of Hygiene & Tropical Medicine)Shah Ebrahim(University College London)Michael Marmot(Johns Hopkins University)W.H. Linda Kao(University of Minnesota)James S. Pankow(National Health Service)Michael Sampson(Kuopio University Hospital)Johanna Kuusisto(Kuopio University Hospital)Markku LaaksoTorben Hansen(Aarhus University)Oluf Pedersen(Eurac Research)Peter P. Pramstaller(Zimmer Biomet (Germany))H.‐Erich Wichmann(Helmholtz Zentrum München)Thomas Illig(University of Split)Igor Rudan(Institute of Genetics and Cancer)Alan F. Wright(Leipzig University)Michael Stümvoll(University of Edinburgh)Harry Campbell(University of Edinburgh)James F. Wilson

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Genetic Associations and Epidemiology Diet, Metabolism, and Disease Pancreatic function and diabetesBiologyInsulin resistanceType 2 diabetesGlucose homeostasisInternal medicineGenome-wide association studyGlycemicEndocrinologyDiabetes mellitusGenetic association

MeSH terms

Delta-5 Fatty Acid DesaturaseAdolescentAdultAllelesBlood GlucoseChildDiabetes Mellitus, Type 2FastingGene Expression RegulationHomeostasisHumansMeta-Analysis as TopicReproducibility of ResultsQuantitative Trait, HeritableGenetic Predisposition to Disease