article Open AccessTop 1% cited
An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings
International Journal of Epidemiology · 2018 · Vol. 48(3) · pp. 713–727
Eleanor Sanderson✉(University of Bristol)George Davey Smith(University of Bristol)Frank Windmeijer(University of Bristol)Jack Bowden(University of Bristol)
Abstract
MVMR analysis consistently estimates the direct causal effect of an exposure, or exposures, of interest and provides a powerful tool for determining causal effects in a wide range of scenarios with either individual- or summary-level data.
Genetic Associations and EpidemiologyAdvanced Causal Inference TechniquesObesity, Physical Activity, DietMendelian randomizationConfoundingColliderCausal inferenceMultivariable calculusInstrumental variableEconometricsSample (material)StatisticsSample size determination
MeSH terms
AdultAgedCognitionEducational StatusFemaleHumansMaleMiddle AgedBody Mass IndexMultivariate AnalysisLeast-Squares AnalysisModels, EconometricMendelian Randomization Analysis
Funding
- University of Bristol
- Medical Research Council
Citations
1,128
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51
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100%
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References
Detecting pleiotropy in Mendelian randomisation studies with summary data and a continuous outcome
Statistics in Medicine · 2015 · 1,818 citations
Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology
Statistics in Medicine · 2007 · 4,904 citations
The Estimation of Economic Relationships using Instrumental Variables
Econometrica · 1958 · 3,350 citations
Estimation and Inference in Econometrics.
The Economic Journal · 1994 · 5,592 citations
Mendelian randomization: genetic anchors for causal inference in epidemiological studies
Human Molecular Genetics · 2014 · 4,933 citations
‘Mendelian randomization’: can genetic epidemiology contribute to understanding environmental determinants of disease?*
International Journal of Epidemiology · 2003 · 6,297 citations
Avoiding Invalid Instruments and Coping with Weak Instruments
The Journal of Economic Perspectives · 2006 · 1,101 citations
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
International Journal of Epidemiology · 2015 · 10,342 citations
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