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PROACT: A Phase II Randomized Trial of Recombinant Pro-Urokinase by Direct Arterial Delivery in Acute Middle Cerebral Artery Stroke

Stroke · 1998 · Vol. 29(1) · pp. 4–11

Gregory J. del Zoppo✉(Scripps Clinic)Randall T. HigashidaAnthony J. FurlanMichael S. PessinHoward A. RowleyMichael Gent

Abstract

Intra-arterial local rpro-UK infusion was associated with superior recanalization in acute thrombotic/ thromboembolic stroke compared with placebo. In this regimen, heparin dose influenced hemorrhage frequency and recanalization. Although symptomatic hemorrhage remains a concern, this study suggests that recanalization is enhanced with rpro-UK and heparin.

Acute Ischemic Stroke Management Cerebrovascular and Carotid Artery Diseases Intracranial Aneurysms: Treatment and ComplicationsMedicineThrombolysisUrokinasePlaceboStroke (engine)Middle cerebral arteryIntracerebral hemorrhageRandomized controlled trialAnesthesiaRandomization

MeSH terms

Acute DiseaseAgedAnticoagulantsCerebral AngiographyCerebral Arterial DiseasesIntracranial Embolism and ThrombosisCerebral HemorrhageBrain IschemiaIschemic Attack, TransientCerebrovascular DisordersDose-Response Relationship, DrugDouble-Blind MethodEnzyme PrecursorsFemaleFibrinolytic Agents

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Guidelines for the Early Management of Patients With Acute Ischemic Stroke