article Open AccessTop 1% cited
A Randomized Trial of Intraarterial Treatment for Acute Ischemic Stroke
New England Journal of Medicine · 2014 · Vol. 372(1) · pp. 11–20
Olvert A. Berkhemer✉(Amsterdam UMC Location VUmc)Puck Fransen(Sint Lucas Andreas Hospital)Debbie Beumer(Maastricht University)Lucie A. van den BergHester F. Lingsma(GGD Haaglanden)Albert J. Yoo(Massachusetts General Hospital)Wouter J. Schonewille(GGD Haaglanden)Jan Albert VosPaul J. NederkoornMarieke J.H. Wermer(St. Antonius Ziekenhuis)Marianne A. A. van WalderveenJulie Staals(Erasmus MC)Jeannette Hofmeijer(Leiden University Medical Center)Jacques A. van OostayenGeert J. Lycklama à Nijeholt(Rijnstate Hospital)Jelis Boiten(Amsterdam UMC Location VUmc)Patrick A. BrouwerBart J. EmmerSebastiaan F. de BruijnLukas C. van DijkL. Jaap Kappelle(Radboud University Nijmegen)Rob H. LoEwoud J. van Dijk(University Medical Center Utrecht)Joost de Vries(Radboud University Nijmegen)Paul L.M. de Kort(University Medical Center)Willem Jan J. van RooijJan S.P. van den BergBoudewijn A.A.M. van HasseltLeo A.M. Aerden(Catharina Ziekenhuis)René J. DallingaMarieke C. Visser(Academic Medical Center)Joost BotPatrick C. Vroomen(Radboud University Nijmegen)Omid EshghiTobien H.C.M.L. Schreuder(University Medical Center Groningen)Roel J.J. HeijboerKoos Keizer(Radboud University Nijmegen)Alexander V. TielbeekHeleen M. den Hertog(GGD Haaglanden)Dick Gerrits(Amsterdam UMC Location VUmc)Renske M. van den Berg‐VosGiorgos B. KarasEwout W. Steyerberg(GGD Haaglanden)H. Zwenneke FlachHenk A. Marquering(Amsterdam UMC Location VUmc)Marieke E.S. Sprengers(Amsterdam UMC Location VUmc)Sjoerd F.M. JenniskensLudo F.M. Beenen(Amsterdam UMC Location VUmc)René van den Berg(Amsterdam UMC Location VUmc)Peter J. Koudstaal(Sint Lucas Andreas Hospital)Wim H. van Zwam(University Medical Center)Yvo B.W.E.M. RoosAad van der LugtRobert J. van Oostenbrugge(Maastricht University)Charles B.L.M. Majoie(Amsterdam UMC Location VUmc)Diederik W.J. Dippel(Sint Lucas Andreas Hospital)
Abstract
In patients with acute ischemic stroke caused by a proximal intracranial occlusion of the anterior circulation, intraarterial treatment administered within 6 hours after stroke onset was effective and safe. (Funded by the Dutch Heart Foundation and others; MR CLEAN Netherlands Trial Registry number, NTR1804, and Current Controlled Trials number, ISRCTN10888758.).
Acute Ischemic Stroke ManagementCerebrovascular and Carotid Artery DiseasesStroke Rehabilitation and RecoveryMedicineOdds ratioModified Rankin ScaleConfidence intervalRandomized controlled trialRandomizationRevascularizationStroke (engine)Internal medicineSurgery
MeSH terms
Acute DiseaseAdultAgedAged, 80 and overCatheterizationBrain IschemiaCombined Modality TherapyFemaleFibrinolytic AgentsHumansMaleMiddle AgedTissue Plasminogen ActivatorUrokinase-Type Plasminogen ActivatorLogistic Models
Funding
- Stryker
- Medac
Citations
6,515
FWCI
404.98
field-weighted impact
References
78
Percentile
100%
vs. same field & year
Citations per year
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Stroke · 2005 · 1,313 citations
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Stroke · 1998 · 1,242 citations
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Stroke · 2003 · 1,508 citations
Thrombolysis with Alteplase 3 to 4.5 Hours after Acute Ischemic Stroke
New England Journal of Medicine · 2008 · 6,559 citations
Guidelines for the Early Management of Patients With Acute Ischemic Stroke
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