review Open AccessTop 1% cited
Memory CD8 T-Cell Differentiation during Viral Infection
Journal of Virology · 2004 · Vol. 78(11) · pp. 5535–5545
E. John Wherry✉(Emory University)Rafi Ahmed(Emory University)
Abstract
Memory CD8 T cells are an important component of protective immunity against viral infections, and understanding their development will aid in the design of optimal vaccines. Recent work has shed light on the complex differentiation process that occurs during a CD8 T-cell response to viral infection
T-cell and B-cell ImmunologyImmune Cell Function and InteractionImmunotherapy and Immune ResponsesBiologyVirologyViral infectionCellular differentiationCD8ImmunologyVirusGeneticsImmune systemGene
MeSH terms
Acute DiseaseAnimalsCell DifferentiationChronic DiseaseHumansImmunologic MemoryViral VaccinesVirus DiseasesT-Lymphocyte SubsetsCD8-Positive T-Lymphocytes
Funding
- Cancer Research Institute
- National Institutes of Health
Citations
858
FWCI
16.54
field-weighted impact
References
143
Percentile
100%
vs. same field & year
Citations per year
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References
Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells
Nature Immunology · 2001 · 1,277 citations
Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo
Nature Immunology · 2000 · 1,578 citations
Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
Nature Immunology · 2003 · 1,806 citations
Local control of the immune response in the liver
Immunological Reviews · 2000 · 604 citations
Lineage relationship and protective immunity of memory CD8 T cell subsets
Nature Immunology · 2003 · 1,836 citations
Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection
Immunity · 1998 · 1,952 citations
Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function
The Journal of Experimental Medicine · 1998 · 1,950 citations
CD4+ T cells are required to sustain CD8+ cytotoxic T-cell responses during chronic viral infection
Journal of Virology · 1994 · 1,145 citations
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