reviewTop 1% cited

The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection

Nature Immunology · 2007 · Vol. 8(3) · pp. 239–245

Arlene H. Sharpe✉(Harvard University)E. John Wherry(The Wistar Institute)Rafi Ahmed(Emory University)Gordon J. Freeman(Harvard University)

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Cancer Immunotherapy and Biomarkers Immune Cell Function and Interaction Immunotherapy and Immune ResponsesAutoimmunityProgrammed cell deathT cellCell biologyFunction (biology)ImmunityBiologyImmunologyPeripheral toleranceImmune system

MeSH terms

AnimalsCommunicable DiseasesHumansImmune ToleranceLymphocyte ActivationAutoimmunityAntigens, CDModels, ImmunologicalIntercellular Signaling Peptides and ProteinsB7-H1 AntigenProgrammed Cell Death 1 Ligand 2 Protein

Funding

Foundation for the National Institutes of Health
National Multiple Sclerosis Society

Citations

1,501

FWCI

33.77

field-weighted impact

References

Percentile

100%

vs. same field & year

Citations per year

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References

B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

Nature Medicine · 1999 · 2,463 citations

Bone marrow mesenchymal progenitor cells inhibit lymphocyte proliferation by activation of the programmed death 1 pathway

European Journal of Immunology · 2005 · 689 citations

Regulation of PD‐1, PD‐L1, and PD‐L2 expression during normal and autoimmune responses

European Journal of Immunology · 2003 · 625 citations

Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8<sup>+</sup> T cell activation and cytolysis

European Journal of Immunology · 2003 · 473 citations

Development of Lupus-like Autoimmune Diseases by Disruption of the PD-1 Gene Encoding an ITIM Motif-Carrying Immunoreceptor

Immunity · 1999 · 2,706 citations

PD-L2 is a second ligand for PD-1 and inhibits T cell activation

Nature Immunology · 2001 · 2,931 citations

Engagement of the Pd-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

The Journal of Experimental Medicine · 2000 · 5,184 citations

Memory CD8 T-Cell Differentiation during Viral Infection

Journal of Virology · 2004 · 858 citations

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