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FOLFIRI Followed by FOLFOX6 or the Reverse Sequence in Advanced Colorectal Cancer: A Randomized GERCOR Study
Journal of Clinical Oncology · 2003 · Vol. 22(2) · pp. 229–237
Christophe Tournigand✉(International Drug Development Institute (Belgium))Thierry André(International Drug Development Institute (Belgium))Emmanuel Achille(International Drug Development Institute (Belgium))Gérard Lledo(International Drug Development Institute (Belgium))Michel Flesh(International Drug Development Institute (Belgium))D. Méry-Mignard(International Drug Development Institute (Belgium))Emmanuel Quinaux(International Drug Development Institute (Belgium))C. Couteau(International Drug Development Institute (Belgium))Marc Buyse(International Drug Development Institute (Belgium))G. Ganem(International Drug Development Institute (Belgium))Bruno Landi(International Drug Development Institute (Belgium))Philippe Colin(International Drug Development Institute (Belgium))Christophe Louvet(International Drug Development Institute (Belgium))Aimery de Gramont(International Drug Development Institute (Belgium))
Abstract
Both sequences achieved a prolonged survival and similar efficacy. The toxicity profiles were different.
Colorectal Cancer Treatments and StudiesHepatocellular Carcinoma Treatment and PrognosisCancer Treatment and PharmacologyFolinic acidIrinotecanFOLFIRIOxaliplatinMedicineFluorouracilInternal medicineBolus (digestion)Colorectal cancerProgression-free survival
MeSH terms
IrinotecanOxaliplatinAdultAgedAntineoplastic Combined Chemotherapy ProtocolsCamptothecinLeucovorinDrug Administration ScheduleFemaleFluorouracilHumansInfusions, IntravenousInjections, IntravenousMaleMiddle Aged
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